Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study

Ahmadloo, Niloofar; Kameli, Parisa; Ansari, Mansour; Mosalaei, Ahmad; Omidvari, Shapour; Nasrollahi, Hamid; Hamedi, Seyed Hassan; Mohammadianpanah, Mohammad

doi:10.30476/mejc.2021.90568.1583

Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study

Document Type : Original Article(s)

Authors

Niloofar Ahmadloo ¹

Parisa Kameli ¹

Mansour Ansari ²

Ahmad Mosalaei ¹

Shapour Omidvari ²

Hamid Nasrollahi ¹

Seyed Hassan Hamedi ¹

Mohammad Mohammadianpanah ³

¹ Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

² Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

³ Colorectal Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/mejc.2021.90568.1583

Abstract

Background: Glioblastoma is the most prevalent and aggressive adult glial tumor. Patients who receive standard treatment have a mean survival of 12-14 months. Zinc is a micronutrient that has shown to have anticancerous effects. In the in vitro studies zinc had antineoplastic effects on gliobalstoma cells.
Method: This is a phase II randomized trial in which 60 patients in two groups were evaluated. The zinc group (29 patients) received zinc sulfate supplement 50 mg orally twice a day and the control group (31 patients) who were selected from historical case sreceived no supplements.
Results: Mean overall survival in the case and control groups were 9.93 (± 3.29) and 9.0 (± 3.56) months. In the case and control groups, the mean disease-free survival were 9.62 (SD ± 3.37) and 8.26 (SD ± 3.47) months. These differences were not statistically significant. Although overall survival and recurrence-free survival in patients in the case group was higher than the control group, there was no statistically significant difference (P = 0.485).
Conclusion: Zinc consumption was associated with better survival, but these differences were not statistically significant, necessitating further studies.

Keywords

Glioblastoma multiforme

Chemotherapy

Radiotherapy

Zinc sulfate

How to cite this article:

Ahmadloo N, Kameli P, Ansari M, Mosalaei A, Omidvari S, Nasrollahi H, et al. Effect of zinc sulfate on overall survival and progression-free survival in patients with glioblastoma multiforme, a phase II study. Middle East J Cancer. 2023;14(1):113-8. doi:10. 30476/mejc.2021.90568.1583.

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