%0 Journal Article %T Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study %J Middle East Journal of Cancer %I Shiraz University of Medical Sciences %Z 2008-6709 %A Ahmadloo, Niloofar %A Kameli, Parisa %A Ansari, Mansour %A Mosalaei, Ahmad %A Omidvari, Shapour %A Nasrollahi, Hamid %A Hamedi, Seyed Hassan %A Mohammadianpanah, Mohammad %D 2023 %\ 01/01/2023 %V 14 %N 1 %P 113-118 %! Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study %K Glioblastoma multiforme %K Chemotherapy %K Radiotherapy %K Zinc sulfate %R 10.30476/mejc.2021.90568.1583 %X Background: Glioblastoma is the most prevalent and aggressive adult glial tumor. Patients who receive standard treatment have a mean survival of 12-14 months. Zinc is a micronutrient that has shown to have anticancerous effects. In the in vitro studies zinc had antineoplastic effects on gliobalstoma cells.Method: This is a phase II randomized trial in which 60 patients in two groups were evaluated. The zinc group (29 patients) received zinc sulfate supplement 50 mg orally twice a day and the control group (31 patients) who were selected from historical case sreceived no supplements.Results: Mean overall survival in the case and control groups were 9.93 (± 3.29) and 9.0 (± 3.56) months. In the case and control groups, the mean disease-free survival were 9.62 (SD ± 3.37) and 8.26 (SD ± 3.47) months. These differences were not statistically significant. Although overall survival and recurrence-free survival in patients in the case group was higher than the control group, there was no statistically significant difference (P = 0.485).Conclusion: Zinc consumption was associated with better survival, but these differences were not statistically significant, necessitating further studies. %U https://mejc.sums.ac.ir/article_48458_26e6f1b4eaba5d142692394cbaaf2ec5.pdf