Document Type : Editorial

Author

Department of Biomedical Sciences, School of Arts and Sciences, Lebanese International University, Khiyara-West Bekaa, Lebanon

10.30476/mejc.2023.97702.1875

Highlights

Sami El Khatib (Google Scholar)

Keywords

Main Subjects

How to cite this article:

El Khatib S. Molecular characterization and metastatic gene signatures based on targeted cancer treatment modalities. Middle East J Cancer. 2024;15(2):87-8. doi: 10.30476/ mejc.2023.97702.1875.

  1. Gupta GP, Massagué J. Cancer metastasis: building a framework. Cell. 2006;127(4):679-95. doi: 10.1016/j.cell.2006.11.001.
  2. Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z. Tumour heterogeneity and metastasis at single-cell resolution. Nat Cell Biol. 2018;20(12):1349-60. doi: 10.1038/s41556-018-0236-7.
  3. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423-37. doi: 10.1038/nm.3394.
  4. Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 1989;8(2):98-101.
  5. Albini A, Mirisola V, Pfeffer U. Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior. Cancer Metastasis Rev. 2008;27(1):75-83. doi: 10.1007/s10555-007-9111-x.
  6. Li F, Tiede B, Massagué J, Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res. 2007;17(1):3-14. doi: 10.1038/sj.cr.7310118.
  7. Wu M, Zhang X, Zhang W, Chiou YS, Qian W, Liu X, et al. Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022;13(1):1371. doi: 10.1038/s41467-022-29018-9.
  8. Wang Z, Zöller M. Exosomes, metastases, and the miracle of cancer stem cell markers. Cancer Metastasis Rev. 2019;38(1-2):259-95. doi: 10.1007/s10555-019-09793-6.
  9. Sancho P, Barneda D, Heeschen C. Hallmarks of cancer stem cell metabolism. Br J Cancer. 2016;114(12):1305-12. doi: 10.1038/bjc.2016.152.
  10. Tyagi A, Wu SY, Sharma S, Wu K, Zhao D, Deshpande R, et al. Exosomal miR-4466 from nicotine-activated neutrophils promotes tumor cell stemness and metabolism in lung cancer metastasis. Oncogene. 2022;41(22):3079-92. doi: 10.1038/s41388-022-02322-w.