Placental site trophoblastic tumor is a subtype of gestational trophoblastic neoplasm with unpredictable clinical behavior. Cytoreductive surgery is the cornerstone of treatment. The aim of this article is to present a case with an unusual site of metastases of placental site trophoblastic tumor. A 35-year-old woman was referred to the academic center of GTN as a persistent case gestational trophoblastic neoplasm for standard treatment. Based on pancreatic metastases in the patient’s work-up, she underwent cytoreductive surgery that resulted in significant improvement in her condition. Proper surgical approach of placental site trophoblastic tumor has a major role in the remission of this disease.