TY - JOUR ID - 45543 TI - FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Shiri, Zahra AU - Mansouri, Reza AU - Haghshenas, Mohammad Reza AU - Talei, Abdolrasoul AU - Erfani, Nasrollah AD - Department of Immunology, Faculty of Medicine, International Branch of Shahid Sadoughi University of Medical Sciences, Yazd, Iran AD - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Breast Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Immunology and Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2019 PY - 2019 VL - 10 IS - 4 SP - 299 EP - 304 KW - Breast cancer KW - FOXP3 gene KW - Single Nucleotide Polymorphism KW - PCR-RFLP DO - 10.30476/mejc.2019.78638. N2 - Background:We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer. Methods: The study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). Polymerase chain reactionrestriction fragment length polymorphism was performed for genotyping. Results: Breast cancer cases had a C allele frequency of 455 (91%) and T allele frequency of 45 (9%). The control group had a C allele frequency of 468 (93.6%) and 32 (6.4%) for the T allele. The CC genotype was present in 206 (82.4%) patients, 43 (17.2%) patients had the CT genotype, and the TT genotype was observed in 1 (0.4%) patient. In the control group, 219 (87.6%) had the CC genotype, whereas 30 (12%) had the CT genotype, and 1 (0.4%) had the TT genotype. Statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (P>0.05). There was no significant association between genotype distribution and patients' clinicopathological factors. Conclusion: Our results do not support an association between the FOXP3 -2383 C/T polymorphism and breast cancer in a population from southern Iran. UR - https://mejc.sums.ac.ir/article_45543.html L1 - https://mejc.sums.ac.ir/article_45543_b052fc37579bded152be65a323991997.pdf ER -