Document Type: Original Article

Authors

1 Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

4 Department of Obstetrics and Gynecology, Yasuj University of Medical Sciences, Yasuj, Iran

Abstract

Background: We conducted the present study to analyze the clinicopathologic features of patients with malignant ovarian germ cell tumor (MOGCT) with recurrence after 2 and 5 years.
Method: In this retrospective and analytical-descriptive study, the obtained data included: age, tumor size, histopathological type, tumor stage, lymph node involvement, ‌laterality of tumor, ‌tumor necrosis, and mitosis. We also evaluated the Cox Regression analysis between these variables with recurrence after 2 and 5 years.
Results: According to our exclusion criteria, we eliminated 81 cases. These cases consisted of the subjects with dysgerminoma (48.1%), immature teratoma (22.2%), yolk sac (16%), mix germ cell (11.1%), non-gestational choriocarcinoma (1.2%), and embryonal carcinoma (1.2%). We did not observe pure polyembryoma or polyembryoma in combination with mixed germ cell.‌All the patients received the treatment. The ‌patients’ mean age was 23.3±8.4 years.‌MOGCT reoccurred in 10 patients after 2 years and in 13 patients after 5 years (10 cases in the first 2 years, and 3 new cases in the next 3 years). Most of the cases (64.2%) were diagnosed to be at stage1. The Cox Regression analysis between positive lymph node and the recurrence of MOGCT after 2 years and between stage IV of disease and the recurrence after 2 years were significant. The Cox Regression analysis between laterality, mitosis and necrosis in pathologic slides of the recurrence after 2 and 5 years was not significant.
Conclusion: Stages and involvement of lymph nodes are two major factors concerning the recurrence of MOGCT. Most recurrences occur in the first 2 years. Pathologic features‌‌‌‌ (mitosis and necrosis) of MOGCt‌ in the time of diagnosis not correlated with the recurrence of the disease.

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This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2020.83404.1160