TY - JOUR ID - 47014 TI - Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors’ Growth and Metastasis in Vivo JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Kefayat, Amirhosein AU - Yuosefzadeh, Mohadeseh AU - Goli, Parvin AU - Babayi, Alireza AU - Rezaei, Abbas AU - Esmaeil, Nafiseh AD - Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Biology, Payame Noor Isfahan University, Isfahan, Iran Y1 - 2021 PY - 2021 VL - 12 IS - 2 SP - 261 EP - 268 KW - Phycocyanin C KW - Breast Neoplasm KW - Metastasis DO - 10.30476/mejc.2020.83064.1130 N2 - Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we employed phycocyanin C for the treatment of 4T1 breast tumor as an applicable experimental animal model for human mammary cancer and metastasis. BALB/c mice were injected subcutaneously (s.c) into the 4th abdominal mammary fat pad with 1×106 4T1 cells. We randomly divided the mice into two groups; one group of mice were injected with PBS as the control, and the other group was intraperitoneally injected with phycocyanin C (80 mg/kg daily for 20 days). Tumor growth and metastasis were assessed in both groups. Results: Phycocyanin C significantly inhibited 4T1 breast tumors growth (P<0.05). The mean tumors volumes at the control group were 2.73 times higher than those of the treatment group. In addition, phycocyanin C treatment could significantly inhibit the formation of metastasis colonies at vital organs like spleen, liver, and lung. Moreover, the survival rate of the tumor-bearing mice increased after about 22 days by phycocyanin C treatment in comparison with the control. Conclusion: This is the first report demonstrating the anticancer effects of phycocyanin C on 4T1 breast tumor in vivo. Overall, our findings provided convincing evidence for the application of phycocyanin C as an anticancer therapeutic agent. UR - https://mejc.sums.ac.ir/article_47014.html L1 - https://mejc.sums.ac.ir/article_47014_0033ae7be4271f1d63c241b8fc17a031.pdf ER -