TY - JOUR ID - 46799 TI - Multimodality Imaging Features of Breast Carcinoma in Women with Neurofibromatosis Type 1 (NF 1) – A Report of Two Cases JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Chan, Wai Yee AU - Hamid, Marlina Tanty Ramli AU - Westerhout, Caroline Judy AU - Tze, Tan Ling AU - Pailoor, Jayalakshmi AU - Rahmat, Kartini AD - Department of Biomedical Imaging, University Malaya Research Imaging Center, University of Malaya, Kuala Lumpur, Malaysia AD - Department of Radiology, Faculty of Medicine, University Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia AD - Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Y1 - 2021 PY - 2021 VL - 12 IS - 1 SP - 151 EP - 159 KW - Neurofibromatosis type 1 KW - Breast cancer KW - Risk factor KW - MRI DO - 10.30476/mejc.2020.81924.1053 N2 - With a prevalence of approximately 1 out of 2,500 to 4,000 births, neurofibromatosis type 1 (NF1), also known as von Recklinghausen’s disease, is one of the most prevalent autosomal dominant diseases in humans. There is four to five-fold increased risk of malignancy in these patients due to the presence of NF1 gene mutation, which is a tumour suppressor inhibiting RAS activation. NF1 is known to be closely associated with central nervous system (CNS) tumours; however, its association with other non-CNS malignancies is not uncommon. Mutation of BRCA1 (breast cancer 1, early onset) and BRCA2 (breast cancer 2, susceptibility protein) genes has long been recognized as an important risk factor for the develpoment of breast cancer. Incidentally, BRCA1 and NF1 genes are both located in the long arm of chromosome 17. The association between NF1 and breast cancer has long been debated; recent studies, on the other hand, have established this association, with NF1 unequivocally identified as breast cancer susceptibility gene conferring a moderate risk of breast cancer development. In this report, we described multimodality imaging features of breast cancer in two women with NF1; we further reviewed the literatures on the association between NF1 and breast cancer and its diagnostic challenge. UR - https://mejc.sums.ac.ir/article_46799.html L1 - https://mejc.sums.ac.ir/article_46799_fe0cd81bf9011d6133d7d09b17887eec.pdf ER -