@article { author = {Subramanian, Vidyalakshmi and Joshna Catherine, Xavier and Murugesan, Rajeswari}, title = {Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis}, journal = {Middle East Journal of Cancer}, volume = {12}, number = {2}, pages = {161-171}, year = {2021}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {10.30476/mejc.2020.83099.1135}, abstract = {Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients. Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software. Results: This retrospective analysis identified the expression patterns of 6645 patients in 36 studies. Expression of TWIST1 correlated with the least prognosis rate (HR= 2.129, 95% CI= 1.373 - 3.302) as compared to SNAIL1 (HR= 1.804, 95% CI= 1.151 - 2.827), SLUG (HR= 1.724, 95% CI= 0.992 - 2.997) and ZEB1 (HR= 1.590, 95% CI= 1.358 - 1.861). Conclusion: These findings suggested the implication of TWIST1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis.}, keywords = {Metastasis,EMT-TFs,Fixed effects model,Cancer prognosis,Biomarker}, url = {https://mejc.sums.ac.ir/article_47046.html}, eprint = {https://mejc.sums.ac.ir/article_47046_5b2cff72ed56262730f773adde3edef0.pdf} }