Document Type : Original Article(s)
Authors
- Dipika Jayachander 1
- Arnadi Ramachandrayya Shivashankara 2
- Mamidipudi Srinivasa Vidyasagar 3
- Raees Tonse 4
- Sarita Pais 5
- Ashwin DL Lobo 2
- Sanath Kumar Hegde 6
- Suresh Rao 6
- Manjeshwar Shrinath Baliga 6
1 Department of Radiation Oncology, Apollo Hospital, Bengaluru, Karnataka, India
2 Department of Biochemistry, Father Miller Medical College, Kankanady, Mangalore, India
3 Department of Radiotherapy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
4 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
5 Department of Radiation Oncology, Narayana Hrudayalaya, Bengaluru, Karnataka, India
6 Department of Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India
Abstract
Background: This study evaluates the predictive significance of salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase in the treatment of head and neck cancer patients who undergo curative radiotherapy/chemoradiotherapy.Methods: The volunteers for the study included head and neck cancer patients that required curative radiotherapy/chemoradiotherapy. Patients provided saliva and blood samples before the start of radiation treatment and 24 h after the first radiation fraction of 2 Gy (before the start of the second fraction). Samples were assessed for the levels of blood and salivary amylase, glutathione, lipid peroxides, and lactate dehydrogenase by standard laboratory methods. Clinical tumor radioresponse was assessed one month after the completion of treatment as complete responders, partial responders, and nonresponders.Results: The results indicated a significant increase in the levels of amylase, lactate dehydrogenase, and lipid peroxides; and a concomitant decrease in the levels of glutathione P
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