Document Type : Case Report(s)
Authors
- Abolfazl Movafagh 1
- Mehrdad Hashemi 2
- Mojtaba Ghadiani 3
- Reza Mirfakhraei 1
- Hossein Darvish 1
- Davood Zare Abdollahi 1
- Hamid Ghaedi 1
- Shamsi Safari 1
- Leyla HaghNejad 1
- Sara Mosammami 1
- Niloofar Safavi Naeini 1
- Ramin Miri 1
- Mostafa Rezaei Tavirani 4
1 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Associate professor of Molecular Genetics, Department of Genetics, Islamic Azad University,Tehran Medical Branch,Tehran,Iran
3 Department of Internal Medicine/Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations.Methods:We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/ chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique.Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype 46,XX,t(9;22;2;5).Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias.
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