Document Type : Original Article(s)

Authors

• Sepideh Shakeri ¹
• Hossein Ayatollahi ¹
• Mohammad Hadi Sadeghian ¹
• Seyyede Fatemeh Shams ²

¹ Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

² Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

Abstract

Background: Chromosomal aberrations which occur in different hematologic malignancies are believed to be highly applicable for identifying the prognosis and treatment protocols. We conducted the present study to investigate the chromosomal and molecular abnormalities in bone marrow of acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and myelodysplastic syndrome patients.
Method: We performed this cross-sectional study in molecular pathology and cancer research center of Mashhad University of Medical Sciences (MUMS), during 2017-2019; the total number of our cases was 252. We did all the molecular and cytogenetic tests on these patients. SPSS V.16 software was utilized for the analysis of our data.
Results: In this research, the ALL patients were meaningfully younger than AML ones. There were significant associations between karyotype patterns and types of malignancy; normal diploid was more frequent in myelodysplastic syndrome (p <0.05). Among numerical abnormalities, trisomy 3 and monosomy 14 were the most prevalent ones.
Conclusion: The results of similar studies from different areas with different ethnics would help to identify new parameters for prognosis determination. Cytogenetic analysis is highly applicable for leukemia diagnosis and prognosis.

Keywords

• Chromosome aberrations
• Hematology
• Cytogenetic analysis
• Leukemia