Document Type : Original Article(s)

Authors

• Mohammad-Ali Mohammadi-Vajari ¹
• Mohammad Reza Babaei ²
• vahid kaveh ³
• Atefe Shafiee ⁴
• Ghazale Tefagh ⁵
• Mohammad Amin Akbarnezhad ⁶

¹ Department of Radiology, Iran University of Medical Sciences, Tehran, Iran

² Associated professor of interventional radiology, department of interventional radiology, Firouzgar hospital, Iran university of medical sciences, Tehran, Iran

³ Medical Oncology and Hematology, Iran University of Medical Sciences, Tehran, Iran.

⁴ Board-certified cardiologist, Rajaie Cardiovascular Medical and Research center, School of Medicine, Iran University of Medical Sciences.

⁵ Radiology Resident, Department of Radiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

⁶ Radiology Resident, Department of radiology, Imam Reza hospital, Army university of medical science

Abstract

Background: Pain is one of the most common symptoms in cancer patients, and celiac block has been introduced as an alternative for patients who are not satisfied with narcotic treatment. The present study aimed to compare the effects of Radiofrequency ablation (RFA) and alcohol injection against alcohol injection alone on celiac ganglion block in patients with primary and metastatic malignancy involving the celiac ganglion.
Methods: In this randomized, single-blind clinical trial, primary and metastatic malignancy patients with unresponsive pain were investigated. Group A only received 90% alcohol bilaterally. Group B received RFA, and alcohol injection. Both methods were performed under Computed Tomography (CT) guidance. Then, patients were followed up for 6 months. All analyses were done with SPSS version 24 software. Spearman’s nonparametric rank, Chi-square, and multivariate analysis were simultaneously used to analyze correlations, compare categorical variables, and analyze variables, respectively. A P-value <0.05 was considered to be statistically significant.
Results: The study participants were 42 patients with a mean age of 64.1 +/- 4.87. Comparing alcohol injection with and without RFA on celiac ganglion block in patients with primary and metastatic malignancy involving the celiac ganglion showed that there is not any significant difference between these two methods (P-value>0.05). Finally, 90.48% of patients in both groups showed at least partial response.
Conclusions: We showed that alcohol injection alone can be an appropriate technique for celiac ganglion block in patients with primary and metastatic malignancy involving celiac ganglion, with no significant difference between alcohol injection alone vs RFA & alcohol injection.

Highlights

Mohammad Reza Babaei (google scholar)

Mohammad-Ali Mohammadi-Vajari (google scholar)

Keywords

• Nerve block
• Radiofrequency ablation
• Palliative Care
• Chemoablation

Main Subjects

• Cancer Imaging and non-surgical Interventions

Please cite this article as: Babaei MR, Akbarnezhad MA, Kaveh V, Mohammadi-Vajari MA, Shafiee A, Tefagh G. Comparing the Effect of RF Ablation and Alcohol Injection vs Alcohol Injection Alone on Celiac Ganglion Block in Patients with Primary and Metastatic Malignancy Involving the Celiac Ganglion: A Randomized Clinical Trial. Middle East J Cancer. 2026; 17(2): p-p. doi: 10.30476/mejc.2025.104776.2206