Middle East Journal of Cancer

Advancing Oral Cancer Detection and Treatment with Nanopore Sequencing Technology

Document Type : Viewpoint

Authors

Anitha Pandi
Vijayashree Priyadharsini Jayaseelan

Clinical Genetics Lab, Centre for Cellular and Molecular Research (The Blue lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, Tamil Nadu, India

https://doi.org/10.30476/mejc.2024.103161.2129

Highlights

Pandi Anitha (PubMed)

Jayaseelan Priyadharsini (PubMed)

Keywords

Diagnosis
Precision medicine
Genetic alterations
Diseases
Subjects

How to cite this article:

Pandi A, Jayaseelan VP. Advancing Oral Cancer Detection and Treatment with Nanopore Sequencing Technology. Middle East J Cancer. 2025;16(4):p-p. doi: 10.30476/mejc.2024.103161.2129.

 

  1. Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M. Oral cancer and precancer: A narrative review on the relevance of early diagnosis. Int J Environ Res Public Health. 2020;17(24):9160. doi: 10.3390/ijerph17249160. PMID: 33302498; PMCID: PMC7764090.
  2. Augustine D, Sowmya SV, Haragannavar VC, Yousef A, Patil S, Gujjar N, et al. Nanopore sequencing technology in oral oncology: A comprehensive insight. J Contemp Dent Pract. 2022;23(2):268-75. PMID: 35748459.
  3. Wang Y, Zhao Y, Bollas A, Wang Y, Au KF. Nanopore sequencing technology, bioinformatics and applications. Nat Biotechnol. 2021;39(11):1348-65. doi: 10.1038/s41587-021-01108-x. PMID: 34750572; PMCID: PMC8988251.
  4. Haque F, Li J, Wu HC, Liang XJ, Guo P. Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA. Nano Today. 2013;8(1):56-74. doi: 10.1016/j.nantod.2012.12.008. PMID: 23504223; PMCID: PMC3596169.
  5. Feng Y, Zhang Y, Ying C, Wang D, Du C. Corrigendum to 'Nanopore-based fourth-generation dna sequencing technology' [GPB 144 (2015) - GPB 13/1 (4-16)]. Genomics Proteomics Bioinformatics. 2015;13(6):383. doi: 10.1016/j.gpb.2016.01.001. Erratum for: Genomics Proteomics Bioinformatics. 2015;13(1):4-16. doi: 10.1016/j.gpb.2015.01.009. PMID: 31283804; PMCID: PMC4747661. 
  6. Wei J, Hong H, Wang X, Lei X, Ye M, Liu Z. Nanopore-based sensors for DNA sequencing: a review. 2024;16(40):18732-66. doi: 10.1039/d4nr01325e. PMID: 39295590.
  7. Zhu L, Xu Z, Gao Y, Sun N, Qiu L, Zhao J. Highly sensitive detection of tumor cell-derived exosomes using solid-state nanopores assisted with a slight salt gradient. ACS Appl Mater Interfaces. 2024;16(37):49218-26. doi: 10.1021/acsami.4c14224. PMID: 39240779.
  8. Levkova M, Chervenkov T, Angelova L, Dzenkov D. Oxford nanopore technology and its application in liquid biopsies. Curr Genomics. 2023;24(6):337-44. doi: 10.2174/0113892029286632231127055733. PMID: 38327653; PMCID: PMC10845067.
  9. Huang X, Duijf PHG, Sriram S, Perera G, Vasani S, Kenny L, et al. Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma. J Biomed Sci. 2023;30(1):65. doi: 10.1186/s12929-023-00953-z. PMID: 37559138; PMCID: PMC10413618.
  10. Dixon K, Shen Y, O'Neill K, Mungall KL, Chan S, Bilobram S, et al. Defining the heterogeneity of unbalanced structural variation underlying breast cancer susceptibility by nanopore genome sequencing. Eur J Hum Genet. 2023;31(5):602-6. doi: 10.1038/s41431-023-01284-1. PMID: 36797466; PMCID: PMC10172360.
  11. Lau BT, Almeda A, Schauer M, McNamara M, Bai X, Meng Q, et al. Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing. Genome Med. 2023;15(1):33. doi: 10.1186/s13073-023-01178-3. PMID: 37138315; PMCID: PMC10155347.
  12. Bjørnstad PM, Aaløkken R, Åsheim J, Sundaram AYM, Felde CN, Østby GH, et al. A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing. Eur J Hum Genet. 2024;32(5):513-20. doi: 10.1038/s41431-023-01494-7. Erratum in: Eur J Hum Genet. 2024;32(5):601-2. doi: 10.1038/s41431-023-01519-1. PMID: 38030917; PMCID: PMC11061271.
  13. Lin B, Hui J, Mao H. Nanopore technology and its applications in gene sequencing. Biosensors (Basel). 2021;11(7):214. doi: 10.3390/bios11070214. PMID: 34208844; PMCID: PMC8301755.
  14. Sakamoto Y, Sereewattanawoot S, Suzuki A. A new era of long-read sequencing for cancer genomics. J Hum Genet. 2020;65(1):3-10. doi: 10.1038/s10038-019-0658-5PMID: 31474751; PMCID: PMC6892365.
  15. Jain M, Koren S, Miga KH, Quick J, Rand AC, Sasani TA, et al. Nanopore sequencing and assembly of a human genome with ultra-long reads. Nat Biotechnol. 2018;36(4):338-45. doi: 10.1038/nbt.4060. PMID: 29431738; PMCID: PMC5889714.
  16. Cretu Stancu M, van Roosmalen MJ, Renkens I, Nieboer MM, Middelkamp S, de Ligt J, et al. Mapping and phasing of structural variation in patient genomes using nanopore sequencing. Nat Commun. 2017;8(1):1326. doi: 10.1038/s41467-017-01343-4. PMID: 29109544; PMCID: PMC5673902.
Middle East Journal of Cancer
Volume 16, Issue 4
Autumn 2025
Pages 384-388

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