Document Type : Case Report(s)

Authors

1 Imam Reza Hospital, Radiation-Oncology Department, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Razavi Hospital, Pathology Department, Mashhad, Iran

10.30476/mejc.2024.102132.2073

Abstract

Pituicytoma, originated from pituicyte cells, is a rare pituitary tumor, especially in children. In 2007, this tumor was classified by WHO as grade 1 CNS tumors. The symptoms of this tumor can be headache, visual or endocrine disorders. Diagnosis is made through imaging and further confirmed by pathology and immunohistochemistry. Treatment is based on surgery, which can be risky due to the proximity to important organs and can also be accompanied by extensive bleeding. Given the low prevalence of the disease and the lack of sufficient information about the treatment of this disease, it is necessary to report the treatments performed in the existing cases to complete the evidence. We present the case of a 9-year-old boy who initially presented with headache and blurred vision, leading to the discovery of pituitary pituicytoma. This rare tumor necessitated a multidisciplinary approach involving neurosurgery and subsequent radiotherapy due to residual tumor presence post-surgery. This case highlights the challenges in diagnosis, surgical intervention, and long-term management of pediatric pituitary pituicytomas.

Highlights

Kazem Anvari (Google Scholar)

Keywords

Main Subjects

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.30476/mejc.2024.102132.2073

  1. Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C. Primary tumors of the posterior pituitary: A systematic review. Rev Endocr Metab Disord. 2019;20(2):219-38. doi: 10.1007/s11154-019-09484-1. PMID: 30864049.
  2. Yasuda ME, Recalde R, Jalón P, Prost D, Golby A, Zaninovich R. Surgical approach to the treatment of pituicytoma. Report of five cases and a literature review. World Neurosurg X. 2023; 19:100186. doi: 10.1016/j.wnsx.2023.100186. PMID: 37026087; PMCID: PMC10070180.
  3. Castellanos LE, Misra M, Smith TR, Laws ER, Iorgulescu JB. The epidemiology and management patterns of pediatric pituitary tumors in the United States. 2021;24(3):412-9. doi: 10.1007/s11102-020-01120-5. PMID: 33433891; PMCID: PMC8415131.
  4. Lefevre E, Bouazza S, Bielle F, Boch AL. Management of pituicytomas: a multicenter series of eight cases. 2018;21(5):507-14. doi: 10.1007/s11102-018-0905-3. PMID: 30062665.
  5. Salge-Arrieta FJ, Carrasco-Moro R, Rodríguez-Berrocal V, Pian H, Martínez-San Millán JS, Iglesias P, et al. Clinical features, diagnosis and therapy of pituicytoma: an update. J Endocrinol Invest. 2019;42(4):371-84. doi: 10.1007/s40618-018-0923-z. PMID: 30030746.
  6. Zygourakis CC, Rolston JD, Lee HS, Partow C, Kunwar S, Aghi MK. Pituicytomas and spindle cell oncocytomas: modern case series from the University of California, San Francisco. 2015;18(1):150-8. doi: 10.1007/s11102-014-0568-7. PMID: 24823438.
  7. Wang J, Liu Z, Du J, Cui Y, Fang J, Xu L, et al. The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma. 2016;36(5):432-40. doi: 10.1111/neup.12291. PMID: 26919073.
  8. El Hussein S, Vincentelli C. Pituicytoma: Review of commonalities and distinguishing features among TTF-1 positive tumors of the central nervous system. Ann Diagn Pathol. 2017;29:57-61. doi: 10.1016/j.anndiagpath.2017.05.004. PMID: 28807344.
  9. Mende KC, Matschke J, Burkhardt T, Saeger W, Buslei R, Buchfelder M, et al. Pituicytoma-An outlook on possible targeted therapies. CNS Neurosci Ther. 2017;23(7):620-6. doi: 10.1111/cns.12709. PMID: 28556544; PMCID: PMC6492650.
  10. Yang X, Liu X, Li W, Chen D. Pituicytoma: A report of three cases and literature review. Oncol Lett. 2016;12(5):3417-22. doi: 10.3892/ol.2016.5119. PMID: 27900014; PMCID: PMC5103963.