Document Type : Poster


1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


Background: Breast cancer, the most prevalent cancer among women, represented 25.4% of all female cancer cases in 2020. Neo-adjuvant chemotherapy has significantly enhanced survival rates and surgical outcomes. This study investigates the pathologic characteristics of breast cancer and their correlations with critical factors in Shiraz, Iran.
Method: This cross-sectional study analyzed 280 pathological reports from Faghihi Hospital in Shiraz, Iran, of patients with histologically confirmed breast cancer; the Named Entity Recognition (NER) technique extracted information from unstructured reports using cancer-related keywords and staging. For structured report sections, text extraction followed specific keyword identification. A physician-supervised the keyword selection and extraction process throughout.
Results: The average tumor size was 32.3 mm, with 1.4% of breast cancer cases occurring in men (female to male ratio = 70:1). Utilizing the Nottingham grading system, it was observed that most tumors were of higher grade, indicating a higher probability of recurrence. As tumors increased in size, tubular, nuclear, and mitotic indices also rose significantly (T: 0.61, N: 0.73, M: 0.73; P < 0.001), suggesting that tumor enlargement not only leads to tissue invasion but also enhances malignant cell aggressiveness. The majority of patients were classified as TNM stage IIA. Patients responding to neo-adjuvant therapy had an average tumor size of 2.13 cm, compared with 4.56 cm in non-responders, with each centimeter increase in size raising the likelihood of treatment failure by 34% (P = 0.015).
Conclusion: The mean tumor size in Iran is approximately double that of some other countries, highlighting the need for an improved screening system. The relatively low female-to-male ratio suggests that male screening could benefit the Iranian demographic. Further research is warranted to establish a size-based threshold for initiating neo-adjuvant therapy.


How to cite this article:

Moghimizadeh MA, Shokrip our M, Hafezi Bafti A, Omidifar N. Pathologic features of breast malignancies undergoing surgery and evaluation of neo-adjuvant therapy efficiency in Shiraz, Iran: A cross-sectional multidimensional study. Middle East J Cancer. 2024;15(2_ Supplement).