Document Type : Original Article(s)


1 Department of Clinical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Anesthesiology and Pain Department, Razavi Research Center, Razavi Hospital, Mashhad, Iran

4 Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5 Department of Radiotherapy and Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran



Background: Current data indicate that serum vitamin D and susceptible C-reactive protein (hs-CRP) levels, both indicative of the inflammatory state, have the potential to predict the onset and severity of chronic pain. Therefore, the objective was to assess the intensity of pain experienced after breast cancer treatment and its relationship with these two parameters.
Method: In this cross-sectional study between 2019 and 2021, 201 patients were enrolled. The McGill Pain Questionnaire was employed to evaluate localized pain intensity at the site six months after the conclusion of cancer treatments. Patients were stratified based on the type of breast surgery, with or without a tissue expander, axillary region surgery, chemotherapy treatment, radiotherapy treatment, serum vitamin D levels, serum hs-CRP levels, and pain intensity. Data analysis was performed using SPSS 21 software with a significance level set at 0.05.
Results: Among the patients, 67.6% (136 individuals) reported mild pain, 31.3% (63 individuals) reported moderate pain, and 1% (2 individuals) reported severe pain. The results of this study demonstrated a positive correlation between high serum hs-CRP levels and increased pain intensity, with serum marker levels being higher in patients experiencing more severe pain compared with those with milder pain. However, no statistically significant association was observed between various serum concentrations of vitamin D and pain intensity (P = 0.12).
Conclusion: Elevated levels of inflammatory factors, such as hs-CRP, are linked to a higher likelihood of developing chronic post-surgical pain.


Ali Taghizadeh (Google Scholar)

Elham Zarei (Google Scholar)


Main Subjects

How to cite this article:

Taghizadeh A, Zarei E, Dehghani M, Joudi M, Fani Pakdel A, Hosseini SM, et al. Investigating post-treatment breast pain severity in breast cancer patients and its correlation with serum vitamin D and hs-CRP levels. Middle East J Cancer. 2024;15(3):207- 16. doi:10.30476/mejc.2023.99172.1941.

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