Document Type : Original Article(s)
Authors
- Maryam Tangarpoor 1
- Bijan Khademi 2
- Maryam Mardani 3
- Mahyar Malekzadeh 4
- Zohreh Jaafari-Ashkavandi 1
1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2 Otolaryngology Research Center, Department of Otolaryngology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4 Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: This study aimed to evaluate serum vitamin D levels in patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in comparison to healthy controls in an Iranian population.
Method: A cross-sectional study was conducted, which included 69 patients with OLP, 40 patients with OSCC, and 60 healthy controls. Serum vitamin D levels were measured using the ELISA method. The data were analyzed using Mann-Whitney and T-tests, and statistical significance was set at P < 0.05.
Results: The study found that 17.9% of OLP patients, 27.25% of OSCC patients, and 25% of the control group had normal vitamin D levels. The mean vitamin D level in OLP patients (17.00 ± 14.16 ng/mL) was significantly lower than that in the control group (22.99 ± 14.46 ng/mL) (P = 0.003). However, in OSCC patients, the mean vitamin D level (24.63 ± 16.19 ng/mL) was not significantly different from that of the control group.
Conclusion: The study revealed a high rate of vitamin D deficiency and insufficiency in OLP, OSCC, and control group patients. Vitamin D deficiency was more common in patients with OLP. Vitamin D deficiency may potentially increase the risk of OLP and OSCC development and progression.
Highlights
Zohreh Jaafari-Ashkavandi (Google Scholar)
Keywords
How to cite this article:
Tangarpoor M, Khademi B, Mardani M, Malekzadeh M, Jaafari-Ashkavandi Z. Vitamin D serum levels in oral lichen planus and oral cancer patients. Middle East J Cancer. 2023;14(4):530-6. doi: 10.30476/mejc.2023.95276.1762.
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