Document Type : Original Article

Authors

1 Department of Internal Medicine, Kosar Hospital, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran

3 Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

4 Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Physical Education and Sport Sciences, Islamic Azad University, Baneh Branch, Baneh, Iran

Abstract

Background: Gastric cancer is one of the most prevalent ones with high incidence and mortality worldwide. The aim of this study was to determine the serum levels of tumor necrosis factor alpha (TNFα) and Interleukin-6 (IL-6) as potential diagnostic biomarkers in first-degree relatives of patients with gastric cancer.  
Method: The present work is a case-control study (case, n = 90; control, n = 90). The cases were selected from first-degree relatives of the gastric cancer patients referred to Kosar Hospital of Semnan city, Iran, during 2019, consecutively. The controls were; however, a random sample from among all the healthy people referred to Blood Transfusion Center of Semnan city in the same year. Demographic, laboratory, and pathological variables were collected from both groups. The levels of IL-6 and TNF-α were measured with ELISA method via platinum ELISA-8-11 kits. STATA 14 software was used for data analysis.
Results: In the case and control groups, 74.44 and 78.79% were male, respectively. Their mean age (SD) was 39.17 (10.75) and 36.16 (10.19) in the case and control groups, respectively. Based on the multivariable logistic regression model, there was a statistically significant difference between the two groups in terms of TNFα (OR = 1.15; 95% confidence interval (CI): 1.02 – 1.30) and smoking (odds ratio (OR) = 3.57; 95% CI: 1.48 – 8.64). However, no statistically significant difference was seen between them concerning the level of IL-6 (OR = 1.0004; 95% CI: 0.97 – 1.03) them.
Conclusion: Increased levels of TNFα might be useful as diagnostic biomarkers in the first-degree relatives of patients with gastric cancer; nonetheless, studies with larger sample size are required.

Keywords

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2022.94412.1724

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