Clear Cell Adenocarcinoma of the Cervix in a Young Woman without Exposure to Diethylstilbestrol: A Case Report

Azimi, Helena; Hassanzadeh, Malihe; Hosseini, Seyede Sepideh; Homaee Shandiz, Fatemeh; Jafarian, Amir Hossein; Azad, Afrooz

doi:10.30476/mejc.2022.89566.1536

Clear Cell Adenocarcinoma of the Cervix in a Young Woman without Exposure to Diethylstilbestrol: A Case Report

Document Type : Case Report(s)

Authors

Helena Azimi ¹

Malihe Hassanzadeh ¹

Seyede Sepideh Hosseini ¹

Fatemeh Homaee Shandiz ²

Amir Hossein Jafarian ³

Afrooz Azad ¹^{, 4}

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

² Department of Radiotherapy, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

³ Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

⁴ Department of Obstetrics and Gynecology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandarabbas, Iran

https://doi.org/10.30476/mejc.2022.89566.1536

Abstract

Clear cell carcinoma is believed to be one of the rare neoplasms of cervix uteri and vagina. The etiology and pathogenesis of clear cell carcinoma of the cervix are unclear, with scarce information about the clinical behavior, optimal management, and prognosis of the tumor. The current treatment options are based on the experiences accumulated on squamous cell carcinoma and other types of adenocarcinoma. Prior intrauterine exposure to diethylstilbestrol (DES) is presumed to be a predisposing factor for clear cell adenocarcinoma in young patients. Metastasis is uncommon, but local recurrence may occur. The cure rate of this disease is 85%-90% in early stages with a small volume of tumors. In this study, we report a rare case of clear cell carcinoma of the cervix in a 21-year-old woman, who had no exposure to DES (in-utero) or synthetic non-steroidal estrogen; therefore, the present research supports the hypothesis that the risk factors, other than DES exposure, play an important role in carcinogenesis.

Keywords

Adenocarcinoma

Clear cell

Diethylstilbestrol

Cervix uteri

How to cite this article:

Azimi H, Hassanzadeh M, Hosseini SS, Homaee Shandiz F, Jafarian AH, Azad A. Clear cell adenocarcinoma of the cervix in a young woman without exposure to diethylstilbestrol: a case report. Middle East J Cancer. 2023;14(2):323-6. doi: 10.30476/mejc.2022.89566.1536.

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