Document Type : Case Report


1 Department of General Surgery, Iran University of Medical Science, Tehran, Iran

2 General Physician, Private Office, Tehran, Iran

3 Department Internal Medicine, Iran University of Medical Science, Tehran, Iran


A solitary fibrous tumor (SFT) of the pleura is a rare chest wall mesenchymal neoplasm which usually arises from CD34-positive sub-mesothelial mesenchymal cells of visceral pleura. It is rare, accounting for less than 5% of all pleural neoplasms. Recently, steroid hormone receptors were recognized in the cells of extra-pleural SFT. Progesterone may participate as a growth factor in many CD34 (+) stromal neoplasms. During pregnancy, the amount of plasma progesterone gradually increases. As a result, it could promote the development of cancers that rely on progesterone. However, the link between SFT and pregnancy has not yet been established. There are only six extra-thoracic SFT-reported cases with accelerated growth during pregnancy, on the literature. Hence, we reported an interesting case of SFT which is the first reported case of thoracic SFT presenting during pregnancy. Moreover, we attempted to clarify the mechanism of this tumor's rapid growth by examining its hormonal receptors status in the cells of this tumor.


How to cite this article:

Tizmaghz A, Shabestanipour G, Iranpour A. A review on solitary fibrous tumor behavior in pregnancy: A case report and literature review. Middle East J Cancer. 2023;14(1):176-83. doi:10.30476/mejc.2022.91196. 1613.

  1. Jeon HW, Kwon SS, Kim YD. Malignant solitary fibrous tumor of the pleura slowly growing over 17 years: case report. J Cardiothorac Surg. 2014;9:113. doi: 10.1186/1749-8090-9-113.
  2. Davanzo B, Emerson RE, Lisy M, Koniaris LG, Kays JK. Solitary fibrous tumor. Transl Gastroenterol Hepatol. 2018;3:94. doi: 10.21037/tgh.2018.11.02.
  3. Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, et al. Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model. Mod Pathol. 2012;25(9):1298-306. doi: 10.1038/modpathol.2012.83.
  4. Tapias LF, Mercier O, Ghigna MR, Lahon B, Lee H, Mathisen DJ, et al. Validation of a scoring system to predict recurrence of resected solitary fibrous tumors of the pleura. Chest. 2015;147(1):216-23. doi: 10.1378/ chest.14-1180.
  5. Sureka B, Thukral BB, Mittal MK, Mittal A, Sinha M. Radiological review of pleural tumors. Indian J Radiol Imaging. 2013;23(4):313-20. doi: 10.4103/ 0971-3026.125577.
  6. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013; 45(2):180-5. doi: 10.1038/ng.2509.
  7. Saynak M, Veeramachaneni NK, Hubbs JL, Okumuş D, Marks LB. Solitary fibrous tumors of chest: Another look with the oncologic perspective. Balkan Med J. 2017;34(3):188-99. doi: 10.4274/ balkanmedj. 2017.0350.
  8. Park MS, Ravi V, Conley A, Patel SR, Trent JC, Lev DC, et al. The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis. Clin Sarcoma Res. 2013;3(1):7. doi: 10.1186/2045-3329-3-7.
  9. Stacchiotti S, Tortoreto M, Baldi GG, Grignani G, Toss A, Badalamenti G, et al. Preclinical and clinical evidence of activity of pazopanib in solitary fibrous tumour. Eur J Cancer. 2014;50(17):3021-8. doi: 10.1016/j.ejca.2014.09.004.
  10. Rochefort H. Endocrine disruptors (EDs) and hormonedependent cancers: Correlation or causal relationship? C R Biol. 2017;340(9-10):439-45. doi: 10.1016/j. crvi.2017.07.007.
  11. Newton HB. Handbook of brain tumor chemotherapy, molecular therapeutics, and immunotherapy. 2nd ed. Academic Press; 2018. doi: 10.1016/C2016-0-02355-0.
  12. Penel N, Amela EY, Decanter G, Robin YM, Marec- Berard P. Solitary fibrous tumors and so-called hemangiopericytoma. Sarcoma. 2012;2012:690251. doi: 10.1155/2012/690251.
  13. Hyde RA, Liu Y, Aakalu VK, Setabutr P. Solitary fibrous tumor of the orbit with growth during pregnancy: a case report. Orbit. 2019;38(3):256-8. doi: 10.1080/01676830.2018.1474930.
  14. Acosta-Gonzalez G, Cho M, Rogers R, Mariz F, Pachter L, Neto A. A rare case of primary hepatic solitary fibrous tumor associated with pregnancy. Case Reports in Clinical Pathology (CRCP). 2016;3(3): 66.doi:10.5430/crcp.v3n3p66.
  15. Peksa M, Boćkowski M, Preis K. Solitary fibrous tumor of the retroperitoneum in pregnancy: case report. [Article in Polish] Ginekol Pol. 2011;82(5):382-5.
  16. Morris R, McIntosh D, Helling T, Martin JN Jr. Solid fibrous tumor of the liver: a case in pregnancy. J Matern Fetal Neonatal Med. 2012;25(6):866-8. doi: 10.3109/14767058.2011.596958.
  17. Das JK, Sharma AS, Deka ACh, Das D. Solitary fibrous tumor of the orbit presenting in pregnancy. Indian J Ophthalmol. 2009;57(3):238-40. doi: 10.4103/0301-4738.49405.
  18. Bongiovanni M, Viberti L, Giraudo G, Morino M, Papotti M. Solitary fibrous tumour of the adrenal gland associated with pregnancy. Virchows Arch. 2000;437(4):445-9. doi: 10.1007/s004280000268.
  19. Liu CC, Wang HW, Li FY, Hsu PK, Huang MH, Hsu WH, et al. Solitary fibrous tumors of the pleura: clinicopathological characteristics, immunohistochemical profiles, and surgical outcomes with long-term followup. Thorac Cardiovasc Surg. 2008;56(5):291-7. doi: 10.1055/s-2007-965767.
  20. Bongiovanni M, Viberti L, Pecchioni C, Papotti M, Thonhofer R, Hans Popper H, et al. Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells. J Pathol. 2002;198(2):252- 7. doi: 10.1002/path.1195.
  21. Schutt RC, Gordon TA, Bhabhra R, Cathro HP, Cook SL, McCartney CR, et al. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report. J Med Case Rep. 2013;7:11. doi: 10.1186/1752-1947-7-11.