Document Type : Case Report

Authors

Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Follicular mycosis fungoides (FMF) is a rare variant of cutaneous T-cell lymphoma which is categorized as a separate entity. In histopathology, malignant lymphocytes selectively surround and infiltrate hair follicles. FMF has different clinical features in comparison with classic MF which is more refractory to treatment and has a worse prognosis.
In the current study, we describe a 42-year-old patient presenting as follicular papules with keratotic spines and alopecia on the scalp, face, and trunk. Histologic examination of the patient’s biopsy revealed follicular and perifollicular T lymphoid cell infiltration without follicular mucinosis. Clonality analysis was interpreted as CD4+ T cell lymphoproliferative disorder. With the final diagnosis of follicular MF, the patient underwent treatment with oral acitretin and topical corticosteroid and psoralen plus ultraviolet A (PUVA). This case in addition to the accompanied review of literature revealed the importance of considering folliculotropic MF in spiny hyperkeratotic papules in seborrheic areas refractory to antifungal treatments.

Keywords

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2022.94274.1719

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