Document Type : Case Report(s)


Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


Folliculotropic mycosis fungoides (FMF) is a rare variant of cutaneous T-cell lymphoma which is categorized as a separate entity. In histopathology, malignant lymphocytes selectively surround and infiltrate hair follicles. FMF has different clinical features in comparison with classic MF which is more refractory to treatment and has a worse prognosis.
In the current study, we describe a 42-year-old patient presenting as follicular papules with keratotic spines and alopecia on the scalp, face, and trunk. Histologic examination of the patient’s biopsy revealed follicular and perifollicular T lymphoid cell infiltration without follicular mucinosis. Clonality analysis was interpreted as CD4+ T cell lymphoproliferative disorder. With the final diagnosis of FMF, the patient underwent treatment with oral acitretin and topical corticosteroid and psoralen plus ultraviolet A (PUVA). This case, in addition to the accompanied review of literature, revealed the importance of considering FMF in spiny hyperkeratotic papules in seborrheic areas refractory to antifungal treatments.


Shatila Torabi (Google Scholar)

Farnaz Ahmadpour (PubMed)

How to cite this article:

Torabi S, Fakhraei S, Tayebi Meibodi N, Ahmadpour F. Spiny hyperkeratosis-like follicular mycosis fungoides: a case report. Middle East J Cancer. 2023;14(3):457-62. doi: 10.30476/ mejc.2022.94274.1719.

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