Document Type : Original Article


1 Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

2 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


Background: Squamous cell carcinoma (SCC) is the most prevalent malignancy of the larynx. Non-squamous cell carcinomas of the larynx are rare and consist of different pathology types.
Method: The present work is a retrospective study of non-SCC of the larynx in the south of Iran during a seven-year period.
Results: Among 517 patients with laryngeal cancers, seven (0.13%) had non-SCC. The mean age was 59.1 (39-71) years, and six were male. The main complaint of two of the patients was neck mass, five cases had hoarseness, and one had dyspnea. One subject had both dyspnea and hoarseness. Out of three cases of neuroendocrine tumor, two had radical surgery and afterwards, radiotherapy (RT) was given for one of them. Both cases are well and disease-free. The other patient was a 58-year-old man and was treated with chemoradiation. He died due to brain metastasis following 12 months. Our patient with osteosarcoma is well controlled with surgery, chemotherapy, and RT. We had two male cases of adenoid cystic carcinoma who had undergone total laryngectomy and supraglottic laryngectomy. Both of them received RT (60 or 70 Gy dose) and both are well after 60 and 48 months. A 51-year-old patient with chondrosarcoma had undergone total laryngectomy, who was well after 36 months.
Conclusion: Treatment of non-SCC of the larynx is an extrapolation from the treatment of the more common site of each pathology type. Further studies are needed to draw a firm conclusion.


How to cite this article:

Hamedi SH, Sadeghyan S, Mohammadianpanah M, Nasrollahi H, Ansari M, Ahmadloo N, et al. Laryngeal cancers with non-squamous cell pathology: Experience of south of Iran. Middle East J Cancer. 2022;13(3):466-71. doi: 10.30476/mejc.2022.87477.1416.

  1. Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, et al. Cancer of the larynx. Crit Rev Oncol Hematol. 2003;47(1):65-80. doi: 10.1016/s1040-8428(03)00017-9.
  2. Angouridakis N, Goudakos J, Karayannopoulou G, Triaridis S, Nikolaou A, Markou K. Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature. Head Neck. 2013;35(6):E187-93. doi: 10.1002/hed.22955.
  3. Zhu Y, Gao L, Meng Y, Diao W, Zhu X, Li G, Gao Z, et al. Laryngeal neuroendocrine carcinomas: A retrospective study of 14 cases. Biomed Res Int. 2015;2015:832194. doi: 10.1155/2015/832194.
  4. Prgomet D, Bilić M, Bumber Z, Manojlović S, Katić V. Mucoepidermoid carcinoma of the larynx: report of three cases. J Laryngol Otol. 2003;117(12):998-1000. doi: 10.1258/002221503322683957.
  5. Naciri S, Bennani-Baiti AA, Glaoui M, Mouzount H, Ghanem S, Essakali L, et al. Mantle cell lymphoma of the larynx: Primary case report. J Med Case Rep. 2012;6:201. doi: 10.1186/1752-1947-6-201.
  6. Li G, Chen J, Zhang S, Lin J, Kong F, Cai F, et al. Adenoid cystic carcinoma of the larynx: A report of two cases. Oncol Lett. 2015;10(4):2303-6. doi: 10.3892/ol.2015.3550.
  7. Blanchard A, Nguyen JB, Daroca P, Friedlander P, Lewin E, Vu J, et al. Rare primary mucosal melanoma of the larynx. Ear Nose Throat J. 2016;95(12):E28-E31.
  8. Peng KA, Grogan T, Wang MB. Head and neck sarcomas: analysis of the SEER database. Otolaryngol Head Neck Surg. 2014 Oct;151(4):627-33. doi: 10.1177/0194599814545747.
  9. Oliveira JF, Branquinho FA, Monteiro AR, Portugal ME, Guimarães AM. Laryngeal chondrosarcoma--ten years of experience. Braz J Otorhinolaryngol. 2014;80(4):354-8. doi: 10.1016/j.bjorl.2014.05.004.
  10. Friedman AD, Burns JA, Lutch MJ, Zeitels SM. Submucosal neoplasms of the laryngeal introitus. J Laryngol Otol. 2012;126(7):706-13. doi: 10.1017/S0022215112000928.
  11. Rzepakowska A, Osuch-Wójcikiewicz E, Bruzgielewicz A, Niemczyk K. Non-epithelial neoplasms of the larynx and hypopharynx - 12 - years of experience. Otolaryngol Pol. 2015;69(5):9-15. doi: 10.5604/00306657.1170420.
  12. Fernández-Aceñero MJ, Larach F, Ortega-Fernández C. Non-epithelial lesions of the larynx: review of the 10-year experience in a tertiary Spanish hospital. Acta Otolaryngol. 2009;129(1):108-12. doi: 10.1080/00016480802008207.
  13. van der Laan TP, Plaat BE, van der Laan BF, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases. Head Neck. 2015;37(5):707-15. doi: 10.1002/hed.23666.
  14. Karatayli-Ozgursoy S, Bishop JA, Hillel AT, Akst LM, Best SR. Non-epithelial tumors of the larynx: a single institution review. Am J Otolaryngol. 2016;37(3):279-85. doi: 10.1016/j.amjoto.2016.01.005.
  15. Myssiorek D, Patel M, Wasserman P, Rofeim O. Osteosarcoma of the larynx. Ann Otol Rhinol Laryngol. 1998;107(1):70-4. doi: 10.1177/000348949810700113.
  16. Chin OY, Dubal PM, Sheikh AB, Unsal AA, Park RC, Baredes S, et al. Laryngeal chondrosarcoma: A systematic review of 592 cases. Laryngoscope. 2017;127(2):430-9. doi: 10.1002/lary.26068.
  17. Mosalleum E, Afrogheh A, Stofberg S, Bezuidenhout AF, Schneider J, Hille J. A review of primary osteosarcoma of the larynx and case report. Head Neck Pathol. 2015;9(1):158-64. doi: 10.1007/s12105-014-0550-8.
  18. Rossi RM, Landas SK, Kelly DR, Marsh WL. Osteosarcoma of the larynx. Otolaryngol Head Neck Surg. 1998;118(3 Pt 1):385-8. doi: 10.1016/S0194-59989870321-3.
  19. Moukarbel RV, Goldstein DP, O'Sullivan B, Gullane PJ, Brown DH, Wang L, et al. Adenoid cystic carcinoma of the larynx: a 40-year experience. Head Neck. 2008;30(7):919-24. doi: 10.1002/hed.20802.
  20. Quimby AE, Caulley L, Rodin D, Purgina B, Eapen L, Shier L, et al. Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature. J Med Case Rep. 2017;11(1):65. doi: 10.1186/s13256-017-1209-3.
  21. Liu M, Liu B, Liu B, Cui X, Yang S, Wang Q, et al. Mucosa-associated lymphoid tissue lymphoma of the larynx: a case report and literature review. Medicine (Baltimore). 2015;94(17):e788. doi: 10.1097/MD.0000000000000788.
  22. Mok JS, Pak MW, Chan KF, Chow J, Hasselt CA. Unusual T- and T/NK- cell non-Hodgkin's lymphoma of the larynx: a diagnostic challenge for clinicians and pathologists. Head Neck. 2001;23(8):625-8. doi: 10.1002/hed.1088.