Document Type : Original Article

Authors

1 Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

3 Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran

4 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/mejc.2021.86775.1372

Abstract

Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.
Method: This was a randomized trial on 100 women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.
Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (36.88 cm2 ± 69.93) and control (83.83 cm2 ± 79.34) groups (P = 0.002). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.
Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.

Keywords

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2021.86775.1372