Middle East Journal of Cancer

The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial

Document Type : Original Article(s)

Authors

Shapour Omidvari 1
Zahra Eskandari 2
Hamid Nasrollahi 2
Niloofar Ahmadloo 1
Mansour Ansari 1
Seyed Hassan Hamedi 2
Nezhat Khanjani 2
Behnam Kadkhodaei 2
Ahmad Mosalaei 2
Mohammad Mohammadianpanah 3

1 Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

3 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/mejc.2021.86775.1372
Abstract
Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side-effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.
Method: This was a randomized trial on 100 women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.
Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (36.88 cm2 ± 69.93) and control (83.83 cm2 ± 79.34) groups (P = 0.002). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.
Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.

Keywords

Breast neoplasms
Radiotherapy
Dermatitis

How to cite this article:

Omidvari S, Eskandari Z, Nasrollahi H, Ahmadloo N, Ansari M, Hamedi SH, et al. The investigation of prophylactic effect of StrataXRT gel on radiation-induced dermatitis in breast cancer patients: a randomized clinical trial. Middle East J Cancer. 2022;13(2):293-8. doi: 10.30 476/mejc.2021.86775.1372.

  1. Geara FB, Eid T, Zouain N, Thebian R, Andraos T, Chehab C, et al. Randomized, prospective, open-label phase III trial comparing mebo ointment with biafine cream for the management of acute dermatitis during radiotherapy for breast cancer. Am J Clin Oncol. 2018;41(12):1257-62. doi: 10.1097/COC.0000000000000460.
  2. Mosalaei A, Nasrolahi H, Shafizad A, Ahmadloo N, Ansari M, Mosleh-Shirazi MA, et al. Effect of oral zinc sulphate in prevention of radiation induced oropharyngeal mucositis during and after radiotherapy in patients with head and neck cancers. Middle East J Cancer. 2010;1(2):69-76.
  3. Ahmadloo N, Kadkhodaei B, Omidvari S, Mosalaei A, Ansari M, Nasrollahi H, et al. Lack of prophylactic effects of aloe vera gel on radiation induced dermatitis in breast cancer patients. Asian Pac J Cancer Prev. 2017;18(4):1139-43. doi:10.22034/APJCP.2017.18.4.1139.
  4. Salvo N, Barnes E, van Draanen J, Stacey E, Mitera G, Breen D, et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr Oncol. 2010;17(4):94-112. doi: 10.3747/co.v17i4.493.
  5. Chan RJ, Blades R, Jones L, Downer TR, Peet SC, Button E, et al. A single-blind, randomised controlled trial of StrataXRT(R) - A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer. Radiother Oncol. 2019;139:72-8. doi:10.1016/j.radonc.2019.07.014.
  6. Ahn S, Sung K, Kim HJ, Choi YE, Lee YK, Kim JS, et al. Reducing radiation dermatitis using a filmforming silicone gel during breast radiotherapy: A pilot randomized-controlled trial. In Vivo. 2020;34(1):413-22. doi: 10.21873/invivo.11790.
  7. Ulff E, Maroti M, Serup J, Nilsson M, Falkmer U. Prophylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: A randomized double blinded study. Radiother Oncol. 2017;122(1):50-3. doi:10.1016/j.radonc.2016.11.013.
  8. Pinnix C, Perkins GH, Strom EA, Tereffe W, Woodward W, Oh JL, et al. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys. 2012;83(4):1089-94. doi:10.1016/j.ijrobp.2011.09.021.
  9. Gu J, Zhu S, Li X, Wu H, Li Y, Hua F. Effect of amifostine in head and neck cancer patients treated with radiotherapy: a systematic review and meta-analysis based on randomized controlled trials. PLoS One. 2014;9(5):e95968. doi: 10.1371/journal.pone.
  10. Wells M, Macmillan M, Raab G, MacBride S, Bell N, MacKinnon K, et al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother Oncol. 2004;73(2):153-62. doi: 10.1371/journal.
    0095968.
  11. Fisher J, Scott C, Stevens R, Marconi B, Champion L, Freedman GM, et al. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation
    Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys. 2000;48(5):1307-10. doi: 10.1016/s0360-3016(00)00782-3.

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us