Document Type : Original Article(s)
Authors
- Zahra Zafari 1
- Hossein Ayatollahi 2
- Tayebeh Sohrabi 1
- Pourya Arbab Jafari 1
- Habibollah Esmaeili 3
- Mohammad Reza Keramati 2
1 Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Social Determination of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: The B-cell-specific Moloney murine leukemia virus integration site1 (BMI-1) is one of the famous members of the Polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. Hence, it is believed to be necessary to further clarify the effects of the BMI-1 clinical.
Method: This cross-sectional study was conducted on 70 acute myeloid leukemia (AML), 70 chronic myeloid leukemia (CML), and 20 healthy individuals, as the control group. We used real-time quantitative polymerase chain reaction in order to assess the BMI-1 level expression and its effect on prognosis in AML patients in the Molecular Pathology Research Center.
Results: The results of the present work indicated that the BMI-1 overexpression was significantly higher in the AML and CML patients compared with that in the healthy controls (P < 0.001). Furthermore, a significant relationship was observed between the BMI-1 overexpression and poor prognosis in the AML patients (Hazard ratio=1.749, P < 0.001, 95% confidence interval = 1.31-2.32). Additionally, BMI- 1high was found in chronic and blastic phase in the CML patients (P < 0.001).
Conclusion: We concluded that investigation of BMI-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia.
Keywords
How to cite this article:
Zafari Z, Ayatollahi H, Sohrabi T, Arbab Jafari P, Esmaeili H, Keramati MR. BMI-1 gene expression in patients with acute and chronic myeloid leukemia in the northeast of Iran. Middle East J Cancer. 2023;14(1):41- 8. doi: 10.30476/mejc.2021. 90564.1580.
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