Middle East Journal of Cancer

BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran

Document Type : Original Article(s)

Authors

Zahra Zafari 1
Hossein Ayatollahi 2
Tayebeh Sohrabi 1
Pourya Arbab Jafari 1
Habibollah Esmaeili 3
Mohammad Reza Keramati 2

1 Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Social Determination of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30476/mejc.2021.90564.1580
Abstract
Background: The B-cell-specific Moloney murine leukemia virus integration site1 (BMI-1) is one of the famous members of the Polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. Hence, it is believed to be necessary to further clarify the clinical effects of  BMI-1.
Method: This cross-sectional study was conducted on 70 acute myeloid leukemia (AML), 70 chronic myeloid leukemia (CML), and 20 healthy individuals, as the control group. We used real-time quantitative polymerase chain reaction in order to assess the BMI-1 level expression and its effect on prognosis in AML patients in the Molecular Pathology Research Center.
Results: The results of the present work indicated that the BMI-1 overexpression was significantly higher in the AML and CML patients compared with that in the healthy controls (P < 0.001). Furthermore, a significant relationship was observed between the BMI-1 overexpression and poor prognosis in the AML patients (Hazard ratio=1.749, P < 0.001, 95% confidence interval = 1.31-2.32). Additionally, BMI- 1high was found in chronic and blastic phase in the CML patients (P < 0.001).
Conclusion: We concluded that investigation of BMI-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia.

Keywords

BMI-1 gene
Acute
Myeloid
Leukemia
Chronic myeloid leukemia
Prognostic effect

How to cite this article:

Zafari Z, Ayatollahi H, Sohrabi T, Arbab Jafari P, Esmaeili H, Keramati MR. BMI-1 gene expression in patients with acute and chronic myeloid leukemia in the northeast of Iran. Middle East J Cancer. 2023;14(1):41- 8. doi: 10.30476/mejc.2021. 90564.1580.

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