Primary Mediastinal Choriocarcinoma in a Female Patient with Vaginal Bleeding: A Case Report

Namdari, Nasrin; Anbardar, Mohammad Hossein; Dehghani, Mehdi

doi:10.30476/mejc.2021.86529.1348

Primary Mediastinal Choriocarcinoma in a Female Patient with Vaginal Bleeding: A Case Report

Document Type : Case Report(s)

Authors

Nasrin Namdari ¹

Mohammad Hossein Anbardar ²

Mehdi Dehghani ³

¹ Hematology and Medical Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

² Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

³ Hematology Research Center, Hematology and Medical Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/mejc.2021.86529.1348

Abstract

Primary mediastinal germ cell tumors accounts for about 3%-15% of the mediastinal malignancies. Nonseminomatous tumors make a small percentage of germ cell tumors. Treatment of mediastinal choriocarcinoma includes initial systemic chemotherapy, followed by complete resection of all residual tumors. However, patients with nonseminomatous tumors have very poor prognosis.

Keywords

Choriocarcinoma

Nonseminomatous germ cell tumor

Mediastinal neoplasms

How to cite this article:

Namdari N, Anbardar MH, Dehghani M. Primary mediastinal choriocarcinoma in a female patient with vaginal bleeding: a case report. Middle East J Cancer. 2022;13(2):372- 6. doi: 10.30476/mejc.2021. 86529.1348.

Davis RD Jr, Oldham HN Jr, Sabiston DC Jr. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987;44(3):229-37. doi: 10.1016/s0003-4975(10)62059-0.
Tanaka Y, Okamura T, Nagai T, Kobayashi D, Kobayashi T, Akita H, et al. A study of patients with primary mediastinal germ cell tumors treated using multimodal therapy. Adv Urol. 2017;2017:1404610.doi: 10.1155/2017/1404610.
Mullen B, Richardson JD. Primary anterior mediastinal tumors in children and adults. Ann Thorac Surg. 1986;42(3):338-45. doi: 10.1016/s0003-4975(10)62751-8.
Mead GM, Stenning SP, Cook P, Fossa SD, Horwich A, Kaye SB, et al. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol. 1997;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594.
Toner GC, Motzer RJ. Poor prognosis germ cell tumors: current status and future directions. Semin Oncol. 1998;25(2):194-202.
Kalhor N, Moran CA. Primary germ cell tumors of the mediastinum: a review. Mediastinum. 2018;2:4.
Moran CA, Suster S. Primary germ cell tumors of the mediastinum: I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer. 1997;80(4):681-90.
Iyoda A, Hiroshima K, Yusa T, Toyozaki T, Fujisawa T, Ohwada H. The primary mediastinal growing teratoma syndrome. Anticancer Res. 2000;20(5C):3723-6.
Hainsworth JD, Greco FA. Extragonadal germ cell tumors and unrecognized germ cell tumors. Semin Oncol. 1992;19(2):119-27.
Batman S, Morgan T, Brunetti M, Strandabø RAU, Micci F, Moffitt M, et al. Primary mediastinal choriocarcinoma in a female patient: Case report and review of the literature. Gynecol Oncol Rep. 2018;26:99-101. doi: 10.1016/j.gore.2018.10.013.
Ganjoo KN, Rieger KM, Kesler KA, Sharma M, Heilman DK, Einhorn LH. Results of modern therapy for patients with mediastinal nonseminomatous germcell tumors. Cancer. 2000; 88(5):1051-6.
Sakurai H, Asamura H, Suzuki K, Watanabe S, Tsuchiya R. Management of primary malignant germ cell tumor of the mediastinum. Jpn J Clin Oncol. 2004;34(7):386-92. doi: 10.1093/jjco/hyh062.
Ranganath P, Kesler KA, Einhorn LH. Perioperative morbidity and mortality associated with bleomycin in primary mediastinal nonseminomatous germ cell tumor. J Clin Oncol. 2016;34(36):4445-6. doi:10.1200/JCO.2016.69.8910.