Document Type: Review Article


1 Department of Biotechnology, PSG College of Technology, PSG College of Technology, Coimbatore, India

2 Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India


Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients.
Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, we employed comprehensive meta-analysis software.
Results: This retrospective analysis identified the expression patterns of 6645 patients in 36 studies. Expression of TWIST1 correlated with the least prognosis rate (HR= 2.129, 95% CI= 1.373 - 3.302) as compared to SNAIL1 (HR= 1.804, 95% CI= 1.151 - 2.827), SLUG (HR= 1.724, 95% CI= 0.992 - 2.997) and ZEB1 (HR= 1.590, 95% CI= 1.358 - 1.861).
Conclusion: These findings suggested the implication of TWIST1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis.


This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2020.83099.1135