Document Type : Review Article(s)

Authors

• Vidyalakshmi Subramanian ¹
• Xavier Joshna Catherine ¹
• Rajeswari Murugesan ²

¹ Department of Biotechnology, PSG College of Technology, Coimbatore, India

² Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, India

Abstract

Background: We conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients.
Method: For the determination of the pooled hazard ratio (HR) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software.
Results: This retrospective analysis identified the expression patterns of 6645 patients in 36 studies. Expression of TWIST1 correlated with the least prognosis rate (HR= 2.129, 95% CI= 1.373 - 3.302) as compared to SNAIL1 (HR= 1.804, 95% CI= 1.151 - 2.827), SLUG (HR= 1.724, 95% CI= 0.992 - 2.997) and ZEB1 (HR= 1.590, 95% CI= 1.358 - 1.861).
Conclusion: These findings suggested the implication of TWIST1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis.

Keywords

• Metastasis
• EMT-TFs
• Fixed effects model
• Cancer prognosis
• Biomarker