Document Type: Original Article

Authors

1 Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

3 Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

4 Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

5 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: The variety of neoadjuvant treatments concerning rectal cancer has led to acute complications. The present study aimed to evaluate and compare the acute complications of short-term (SC) and long-term (LC) radiotherapy.
Method: We studied 100 patients suffering from rectal cancer, who referred to Nemazee Hospital before their surgery, in this cross-sectional study. The patients were divided into two categories: SC (25 grays radiotherapy at 5 fractions in 5 days) and LC (chemo-radiotherapy with a dose of 45-50.4 grays in 25- 28 fraction in 5-6 weeks with concurrent Capecitabine (825 mg / m2) twice daily and five days a week). Subsequently, we evaluated them for acute complications in the SC group 10-14 days after the end of the treatment and in the LC group at intervals of the treatment, the end of it and 2 weeks afterwards.
Results: In the LC group compared to the SC group, the percentage of patients with grade 1 diarrhea, grade 2 colitis and grade 1 cystitis at the end of the treatment was statistically different (p <0.001, P=0-046, P=0.036 ). In addition, the total number of the patients with grade 1 and 2 dermatitis was higher in the LC group compared to that in the SC group (P=0.046). We observed no significant differences between the two groups concerning the severe acute complications (P>0.05).
Conclusion: this study implied that there were no significant differences regarding severe acute complication between the two groups.

Keywords

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination, and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.30476/mejc.2020.83111.1133