Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer

Elfeky, Mariem A.; Harb, Ola A.; El Shafaay, Basant Sh; Obaya, Ahmed A.; Awd, Amr A.; Alkilany, Mohamed M.; Gertallah, Loay M.

doi:10.30476/mejc.2020.82884.1115

Prognostic and Clinicopathological Implications of NUSAP1, MELK and L1CAM Immunohistochemical Expression in Cervical Cancer

Document Type : Original Article(s)

Authors

Mariem A. Elfeky ¹

Ola A. Harb ¹

Basant Sh El Shafaay ²

Ahmed A. Obaya ²

Amr A. Awd ³

Mohamed M. Alkilany ⁴

Loay M. Gertallah ⁴

¹ Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

² Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt

³ Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt

⁴ Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egyp

https://doi.org/10.30476/mejc.2020.82884.1115

Abstract

Background: Evaluation of cancer cervix prognosis is highly needed for novel targeted therapy and improved outcomes. Nucleolar and spindle associated protein 1 (NUSAP1) is a novel biomarker that has roles in spindle formation and mitotic progression. Maternal embryonic leucine zipper kinase (MELK) is involved in cell cycle control and carcinogenesis. The L1 cell adhesion molecule (L1-CAM) plays an essential role in cell migration. This study aimed to investigate NUSAP1, MELK, and L1CAM immunohistochemical expression in cancer cervix tissues and detect their prognostic roles.
Method: In this prospective cohort study, we evaluated NUSAP1, MELK, and L1CAM expressions of sections from 62 cervical carcinoma cases using immunohistochemistry.
Results: NUSAP1, MELK, and L1CAM expression correlated with tumor high grade, advanced FIGO stage, poor survival rates, and higher recurrence rate after successful therapy (p <0.001).
Conclusion: Expression of NUSAP1, MELK, and L1CAM in cancer cervix was associated with poor prognosis.

Keywords

Cancer cervix

Immunohistochemistry

Prognosis

NUSAP1

MELK

L1CAM

How to cite this article:

Elfeky M, Harb O, El Shafaay B, Obaya A, Awd A, Alkilany M, et al. Prognostic and clinicopathological implications of NUSAP1, MELK and L1CAM immunohistochemical expression in cervical cancer. Middle East J Cancer. 2021;12 (2):172-82. doi:10.30476/mejc. 2020.82884. 1115.

This article has been partically presented in BGICC-Breast Gynecological and Immuno-Oncology International Cancer Conference 2020 and published in Tumori Journal: Vol 106, Issue 1 - suppl, April 2020.