Middle East Journal of Cancer

Successful Management of Neuroblastoma with Leptomeningeal Metastasis: An Interesting Case

Document Type : Case Report(s)

Authors

Babak Abdolkarimi 1
Aarash Alghasi 2
Mona Moeini 3
Mozhgan Hashemieh 4
Shahab Forutani 5

1 Department of Pediatric Hematology and Oncology, Lorestan University of Medical Sciences, Khoramabad, Iran

2 Department of Pediatric Hematology and Oncology, Ahvaz University of Medical Science, Ahvaz, Iran

3 Mahak Pediatric Cancer Center, Tehran, Iran

4 Department of Pediatric Hematology and Oncology, Shahid Beheshti University of Medical Science, Tehran, Iran

5 General Physician, Lorestan University of Medical Sciences, Khoramabad, Iran

https://doi.org/10.30476/mejc.2019.78706.0
Abstract
Neuroblastoma is an extracranial solid tumor that is most commonly observed in children, yet it is rare to have brain metastasis in neuroblastoma during primary involvement or relapse. In this article, we report a successful treatment of high risk neuroblastoma with primary leptomeningeal metastasis based on developing countries facilities and explain combination chemotherapy (a classic regimen with salvage regimen based on temozolamid and methotroxate intratechal chemotherapy and localized radiation therapy) as a multimodal therapy.

Keywords

Neuroblastoma
Brain metastasis
Leptomeningeal metastasis

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