Middle East Journal of Cancer

A Rare Presentation of Acute Myelogenous Leukemia: A Case Report of Vaginal and Uterine Myeloid Sarcoma from Iran

Document Type : Case Report(s)

Authors

Sina Salari 1
Ali Darakhshandeh 2
Roohollah Gholampour Shahaboddini 3
Azadeh Moghaddas 4

1 Department of Medical Oncology- Hematology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Department of Medical Oncology- Hematology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

https://doi.org/10.30476/mejc.2019.78601.
Abstract
Myeloid or granulocytic sarcoma is an extramedullary tumor of immature granulocytic cells. This condition is rare and has a challenging diagnosis, relying on a high index of suspicion as well as radiology, histology, immunophenotyping, and molecular analyses. We herein report a case of a 25-year-old woman presented with vaginal bleeding and a large pelvic mass involving the vaginal and uterus. A biopsy and immunohistochemical examination of the mass revealed granulocytic sarcoma, and a subsequent bone marrow biopsy confirmed the diagnosis of acute myelogenous leukemia. The patient was treated based on the standard chemotherapy followed by allogeneic bone marrow transplantation from her full-matched sibling donor. After a 9-months follow-up, there was no notable complication, and the patient is now completely disease-free. Granulocytic sarcoma of the cervix is rare, and awareness of this entity is required for timely diagnosis and effective treatment.

Keywords

Granulocytic sarcomas
Acute myelogenous leukemia
Immunohistochemical
Myeloid sarcoma

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