Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report

Hasanzadeh, Malihe; Yousefi, Zohreh; Jafarian, Amir Hosein; Saeed, Shohreh; Shirinzadeh, Laya; Davachi, Behrouz; Farazestanian, Marjaneh

doi:10.30476/mejc.2018.42136

Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report

Document Type : Case Report(s)

Authors

Malihe Hasanzadeh ¹

Zohreh Yousefi ¹

Amir Hosein Jafarian ²

Shohreh Saeed ³

Laya Shirinzadeh ¹

Behrouz Davachi ⁴

Marjaneh Farazestanian ¹

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

² Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

³ Gynecologist Oncologist, Fellowship of Gynecology Oncology, Mashhad, Iran

⁴ Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30476/mejc.2018.42136

Abstract

Squamous cell carcinoma is one of the common malignancies among women, especially in the third and fourth decades of life. Human papillomavirus is the most important cause of squamous cell carcinoma among women worldwide. Early diagnosis and treatment of this carcinoma can prevent disease progression. Herein, we present the case of a pregnant woman with squamous cell carcinoma. A 35-year-old pregnant woman referred to our clinic for cervical cerclage. During the procedure, the gynecological surgeon observed a suspicious lesion. Accordingly, cervical conization was performed and a squamous cell carcinoma lesion was confirmed by the pathology reports. Neoadjuvant chemotherapy was initiated for the patient during pregnancy. Radical hysterectomy and bilateral lymphadenectomy were conducted toward caesarean section. As the patient was a young fertile woman, the ovaries were saved. Although chemotherapy is not a standard treatment for cervical cancer in pregnancy, but neoadjuvant chemotherapy followed by radical hysterectomy and bilateral pelvic lymphadenectomy during cesarean section was a successful treatment in our patient.

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