Document Type : Original Article

Authors

1 Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Reza Radiotherapy Oncology Center, Mashhad, Iran

3 Molecular Medicine Group, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: Breast cancer can be categorized into different histopathological subtypes based on gene expression profiles. The aim of this study was to evaluate the clinicopathological features and overall survival (OS) of various subtypes of breast cancer in order to help diagnosis and guide treatment. Method: The clinicopathologic features of 1095 patients with breast cancer diagnosed over a 10–year period between 2001 and 2011were analyzed. Kaplan–Meier method was used to analyze the disease-free survival (DFS) and overall survival (OS). Calculation of hazard ratio (HR) was conducted by multivariate Cox regression.Results: According to the clinicopathologic characteristics of 1095 cases, 42% were luminal A subtype, 19.2% luminal B, 23% triple negative and 15% Her-2+. The lowest (46.88±12.59 years) and highest (50.54±12.32 years) mean age were in triple negative and Her2+ groups, respectively. There was a significant correlation between histology subtype and age, BMI, lymph node, type of surgery, and stage of disease. Overall survival (OS) and disease free survival (DFS) were significantly shorter in Her-2+ breast cancer patients (P< 0.001). Multivariate analysis showed that age had the highest hazard ratio of 2.481(CI 1.375- 4.477).Conclusion: The results of this study showed the importance of clinicopathological studies of molecular types which helps early diagnosis and identification of best strategy to treat the disease.