1
Laboratory of Genetics and Molecular Pathology, Medical School, University Hassan II, Casablanca, Morocco
2
Department of Onco-Hematology, Ibn Rochd University Hospital, Casablanca, Morocco
Abstract
Background: Acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. The present case-control study measures the relationship between glutathione S-transferase (GST) T1 and M1 null genotypes and the risk of acute myeloid leukemia.Methods: We identified the GSTT1 andGSTM1 genotypes by multiplex polymerase chain reaction in 129 acute myeloid leukemia patients and 129 controls.Results: Individuals that carried GSTT1 null had a risk of acute myeloid leukemia when compared to GSTT1 present carriers (OR: 2.80; 95% CI: 1.63-4.80, P=0.00036). However, GSTM1 null did not influence the risk for acute myeloid leukemia (OR: 1.20; 95% CI: 0.72-1.97, P=0.53). The combined GSTT1 null/GSTM1 present genotype showed an association with the risk for acute myeloid leukemia compared to those that carried both functional genotypes (OR: 8.85; 95% CI: 3.09-23.8, P=0.0001). The double null genotype also showed an association with the risk for acute myeloid leukemia (OR: 2.32, 95% CI: 1.15-4.66, P=0.019).Conclusion: Both GSTT1 null and GST double-null genotypes may be risk factors for acute myeloid leukemia. Further studies are needed to confirm these results.
Oum Kaltoum, A. B., Sellama, N., Hind, D., Yaya, K., Mouna, L. & Asma, Q. (2017). Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population. Middle East Journal of Cancer, 8(1), 7–12.
MLA
Oum Kaltoum, A. B., Sellama, N., Hind, D., Yaya, K., Mouna, L., & Asma, Q. "Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population", Middle East Journal of Cancer, 8, 1, 2017, 7–12.
HARVARD
Oum Kaltoum, A. B., Sellama, N., Hind, D., Yaya, K., Mouna, L., & Asma, Q. (2017). 'Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population', Middle East Journal of Cancer, 8(1), pp. 7–12.
CHICAGO
Oum Kaltoum, A. B., Sellama, N., Hind, D., Yaya, K., Mouna, L. & Asma, Q., "Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population." Middle East Journal of Cancer, 8 1 (2017): 7–12,
VANCOUVER
Oum Kaltoum A. B., Sellama N., Hind D., Yaya K., Mouna L., Asma Q. Association of Glutathione S-transferase Genes (M1 and T1) with the Risk of Acute Myeloid Leukemia in a Moroccan Population. Middle East Journal of Cancer. 2017;8(1):7–12.
