Shiraz University of Medical Sciences, Hematology Research Center, Shiraz, Iran
Abstract
We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to the presence of lambda-type light chains. The patient was treated with desmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.
Dehghani, M. & Karimi, V. M. (2012). Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma. Middle East Journal of Cancer, 3(Issue 2-3), 89–92.
MLA
Dehghani, M., & Karimi, V. M. "Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma", Middle East Journal of Cancer, 3, Issue 2-3, 2012, 89–92.
HARVARD
Dehghani, M., & Karimi, V. M. (2012). 'Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma', Middle East Journal of Cancer, 3(Issue 2-3), pp. 89–92.
CHICAGO
Dehghani, M. & Karimi, V. M., "Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma." Middle East Journal of Cancer, 3 Issue 2-3 (2012): 89–92,
VANCOUVER
Dehghani M., Karimi V. M. Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma. Middle East Journal of Cancer. 2012;3(Issue 2-3):89–92.
