Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review

Movafagh, Abolfazl; Hashemi, Mehrdad; Ghadiani, Mojtaba; Mirfakhraei, Reza; Darvish, Hossein; Zare Abdollahi, Davood; Ghaedi, Hamid; Safari, Shamsi; HaghNejad, Leyla; Mosammami, Sara; Safavi Naeini, Niloofar; Miri, Ramin; Rezaei Tavirani, Mostafa

Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review

Document Type : Case Report(s)

Authors

Abolfazl Movafagh ¹

Mehrdad Hashemi ²

Mojtaba Ghadiani ³

Reza Mirfakhraei ¹

Hossein Darvish ¹

Davood Zare Abdollahi ¹

Hamid Ghaedi ¹

Shamsi Safari ¹

Leyla HaghNejad ¹

Sara Mosammami ¹

Niloofar Safavi Naeini ¹

Ramin Miri ¹

Mostafa Rezaei Tavirani ⁴

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

² Associate professor of Molecular Genetics, Department of Genetics, Islamic Azad University,Tehran Medical Branch,Tehran,Iran

³ Department of Internal Medicine/Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

⁴ Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations.Methods:We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/ chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique.Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype 46,XX,t(9;22;2;5).Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias.