TY - JOUR ID - 48461 TI - The Impact of Body Mass Index on Pathological Response and Survival Outcome after Neoadjuvant Chemotherapy in Localized Bladder Cancer JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Mohammed, Amrallah AU - Elsayed, Fifi AU - Salem, Reham AD - Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt AD - Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University, Egypt AD - Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt Y1 - 2023 PY - 2023 VL - 14 IS - 1 SP - 136 EP - 145 KW - Urinary bladder neoplasms KW - Body mass index KW - Neoadjuvant chemotherapy DO - 10.30476/mejc.2022.90799.1591 N2 - Background: Neoadjuvant chemotherapy (NAC) grants a modest survival benefit in localized muscle-invasive bladder cancer (MIBC). We evaluated the pathological response and survival outcome after NAC in stage II and IIIA MIBC and their correlation with body mass index (BMI).Method: Our retrospective study included stage II (T2 N0) and IIIA (T3 N0, T4 N0, T1-4 N1) MIBC. They received NAC followed by radical cystectomy. The patients were categorized into level I: a BMI of 18.5 – 24.9 kg/m2, level II: a BMI of 25-29.9 kg/m2, and level III: a BMI of ≥ 30 kg/m2.Results: 103 patients with localized MIBC were included. The median age was 63 years; 35 patients (34.0%) belonged to level I, 40 patients (38.8%) belonged to level II, and 28 patients (27.2%) belonged to level III. Smoking status was more common in level II (51.0%) and level III (36.7%) (P < 0.001). Only 18 patients had ECOG PS 2, all belonging to level III (P < 0.001). After NAC, the pCR was 34.3%, 25%, and 10.7% of level I, level II, and level III (P = 0.03), respectively. Of 19 patients who passed away, 10 patients belonged to level III and 6 patients belonged to level II (P = 0.007). For level I, level II, and level III, the disease-free survival was 23.2 months, 12.7 months, and 10.7 months and the overall survival was 61.9, 52.3, and 28.7 months, respectively.Conclusion: Obesity and overweight could be predictive and prognostic markers in localized MIBC. These factors are associated with low pCR after NAC, poor disease-free survival, and overall survival. UR - https://mejc.sums.ac.ir/article_48461.html L1 - https://mejc.sums.ac.ir/article_48461_e789b2d1ec9e8158004830ab88864634.pdf ER -