TY - JOUR ID - 47025 TI - Survival Analysis of Iranian Patients with Breast Cancer Using Joint Frailty Model with a Cure Rate JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Arab Borzu, Zahra AU - Baghestani, Ahmad Reza AU - Talebi Ghane, Elaheh AU - Saeedi, Anahita AU - Akhavan, Ali AD - Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Physiotherapy Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Modeling of Non-communicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran AD - Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2021 PY - 2021 VL - 12 IS - 2 SP - 228 EP - 234 KW - Breast KW - Cure KW - Cohort KW - Joint model KW - frailty KW - Survival DO - 10.30476/mejc.2020.83172.1142 N2 - Background: Breast cancer is a common disease among women around the world. In Iran, it is the most prevalent cancer diagnosed in women. The objective of this study was to assess the cure rate of patients and the associated risk factors. Method: A retrospective cohort study was conducted on 446 patients with breast cancer admitted to the Shahid Ramezanzadeh Radiotherapy Center. Using R 3.2.2 software, the Kaplan-Meier curve, log-rank test, and cure joint frailty model were utilized in the analysis. Results: Of the 446 patients, 17.3% died, 20% experienced relapse, and 62.7% were censored. The 1-5-7-year disease-free survival rates were 95.3%, 73.4%, and 69.3%, respectively. In the cure model, stage, involved lymph node, and surgery were statistically significant. In the recurrence model, stage, involved lymph node, lymphovascular invasion, and hormone therapy were statistically significant. In the death model, stage, lymphovascular invasion, and involved lymph node had a statistically significant effect on the survival time. Conclusion: The cure joint frailty model is a good model when there is a high fraction of patients who do not experience any recurrence or death. In addition, this model allows for the separate estimation of explanatory variable effect on recurrence, death, and cure. The findings of our study can be conducive to preventing the unfavorable effects of breast cancer and increasing the survival of patients. UR - https://mejc.sums.ac.ir/article_47025.html L1 - https://mejc.sums.ac.ir/article_47025_c6dcf6067d4c63df1376a01de7ed8701.pdf ER -