TY - JOUR ID - 41913 TI - Serum HER2 Level in Epithelial Ovarian Cancer JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Mojtahedi, Zahra AU - Solati Dalaki, Sharareh AU - Samsami Dehaghani, Alamtaj AU - Robati, Minoo AU - Monabati, Ahmad AU - Fattahi, Mohammad Javad AU - Ghaderi, Abbas AD - Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2010 PY - 2010 VL - 1 IS - 2 SP - 65 EP - 68 DO - N2 - Introduction: The proto-oncogene HER2 plays a key role in the control of cellular proliferation. Its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer.Materials and Methods: In the present study, serum HER2 levels were investigated in patients diagnosed with epithelial ovarian cancer. Serum HER2 levels were detected by an ELISA commercial kit in 51 patients and 33 healthy individuals.Results: The mean serum HER2 level was found to be significantly higher in patients than healthy controls (P=0.005). In 29% of patients, serum HER2 levels were higher than the cut-off value. HER2 serum level was not associated with tumor stage at diagnosis.Conclusion: Elevation of HER2 in a high proportion of patients with epithelial ovarian cancer further strengthens the importance of this molecule in the pathogenesis of ovarian cancer. UR - https://mejc.sums.ac.ir/article_41913.html L1 - https://mejc.sums.ac.ir/article_41913_8ee4ecb4c217c81ed2130f20b410bf90.pdf ER -