ORIGINAL_ARTICLE
Malignant Tumors of the Larynx: A Clinicopathological Study of 30 Cases
Background: Cancer of the larynx is a common cancer of the head and neck. This cancer has an established correlation with smoking tobacco and alcohol as causative agents. This study has been conducted in a tertiary hospital in Northeastern India. Minimal data about laryngeal cancer from this area was published in the literature.Methods: This prospective study was conducted for a period of two years and enrolled 30 patients. Patients were diagnosed, staged, and treated for the cancer, then followed for 12 months.Results: This study showed that patients in the sixth decade of life were the most common patients that presented with this cancer. There was a male preponderance. Smoking and alcoholism were the most common associated risk factors. Most patients presented with hoarseness followed by a foreign body sensation in the throat. The majority presented with late stage disease. The most common larynx tumor in this study was glottic carcinoma. All cases were squamous cell carcinoma and most were moderately differentiated. Patients underwent treatment with radiation therapy and chemotherapy.Conclusion: At the one year follow up, 36.67% of patients were found to be in remission. A total of two patients succumbed to this disease.
https://mejc.sums.ac.ir/article_41991_ad7ca52d5b788484f1e4c050d441ccf0.pdf
2015-04-01
71
78
J Sathish
Kumar
docsatis@gmail.com
1
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
LEAD_AUTHOR
Nim Narboo
Bhutia
drnnbhutia@gmail.com
2
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
AUTHOR
Tenzing Jigmee
Bhutia
dr.foxd@gmail.com
3
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
AUTHOR
Pradip
Malik
sathish_kumar0007@yahoo.co.in
4
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
AUTHOR
Madhumangol
Singh
diagrammasathish@gmail.com
5
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
AUTHOR
H Priyoshakhi
Devi
6
Department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal, India
AUTHOR
ORIGINAL_ARTICLE
Pro-Oxidant - Antioxidant Balance in Patients with High Grade Glioblastoma Multiform
Background: Gliomas are the most common primary brain tumors of the central nervous system. Among a number of different bio-molecular events, molecular connections between oxidative stress pathways and their development is prevalent. Oxidative stress is the consequence of an imbalance between pro-oxidant factors and antioxidant defense. This imbalance may lead to DNA damage and changes in growth and function of cells in the brain. Many evidences show that reactive oxygen species in the mammalian brain are directly responsible for cell and tissue function and dysfunction. A brain tumor is correlated with oxidative stress. In this study, we determine the pro-oxidant – antioxidant balance in patients with grade IV brain tumors (glioblastoma multiforme) by the pro-oxidant – antioxidant assay.Methods: We collected sera from 50 patients with high grade (IV) glioblastoma multiform and 49 healthy subjects. The pro-oxidant - antioxidant assay was measured.Results: There was a significant increase in pro-oxidant - antioxidant values in patients (158.10±85.71 HK unit) compared to the control group (74.54±33.54 HK; P=0.001.Conclusion: The pro-oxidant - antioxidant balance assay can show a high level of pro-oxidants in the sera of patients with glioblastoma which indicates the presence of oxidative stress in this group.
https://mejc.sums.ac.ir/article_41994_5d749a12b403a7162bc4f02e0a57e548.pdf
2015-04-01
79
83
10.30476/MEJC-2015-204
Mohammad
Faraji-Rad
farajim@mums.ac.ir
1
Department of Neurosurgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mehdi
Khajavi
drkhajavi@yahoo.com
2
Department of Neurosurgery, Emdad Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Hassan
Arjmand
arjmandmh1@yahoo.com
3
Department of Surgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Esmat
Shajari
shajarie1@mums.ac.ir
4
Department of Neurosurgery, Ghaem Academic Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Daryoush
Hamidi Alamdari
hamidiad@mums.ac.ir
5
Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Different Fractionation in Whole Brain Irradiation for Multiple Brain Metastases
Background: This study compared the efficacy of two commonly used fractionation schedules for palliative whole brain irradiation in patients with brain metastases, and assessed the association of the Radiotherapy Therapy Oncology Group (RTOG) Recursive Partitioning Analysis for brain metastases (RPA) to survival with each schedule.Methods: Patients with multiple (more than three) brain metastases were assigned to receive whole brain irradiation in 20 Gy over 5 fractions (group 1) or 30 Gy over 10 fractions (group 2). Primary outcome was response and overall survival in each group. Secondary outcome was the RPA classification relation to overall survival and its possible role in the choice between schedules.Results: There were 54 patients in group 1 and 39 in group 2. There was no significant difference in response (P=0.67) or overall survival between the two groups (P=0.55). However RPA 1 patients had significantly better overall survival than RPA 2 patients in both group 1 (P=0.02) and group 2 (P=0.0014), but no significant difference was found when overall survival of RPA 1 patients of both groups were compared (P=0.47) or that of RPA 2 patients in both groups (P=0.29). Conclusion: The two schedules assessed are comparable in terms of response and overall survival. RPA 1 patients have better overall survival than RPA 2 patients regardless of the fractionation used. A schedule of 20 Gy over 5 fractions should be routinely considered for RPA 2 patients as they are less likely to experience late toxicity. This schedule may be considered for RPA 1 patients, however larger randomized trials are needed to confirm the results and assess differences in neurocognitive function.
https://mejc.sums.ac.ir/article_41995_f7dba18ddd80941efc31120359bff587.pdf
2015-04-01
85
90
Mona
Sayed
mmsaamz@yahoo.com
1
South Egypt Cancer Institute, Assiut University, Assiut, Egypt
LEAD_AUTHOR
ORIGINAL_ARTICLE
Comparison of Cytological versus Histopathological Grading of Invasive Ductal Carcinoma of the Breast with Correlation of Lymph Node Status
Background: Invasive ductal carcinoma is one of the most common type of tumors in females, constituting a single large group of breast cancers. There are various prognostic factors, of which tumor grade, size and axillary lymph node metastasis are among the important ones. Fine needle aspiration cytology is a commonly used diagnostic technique in the initial evaluation of breast lumps. In the era of neoadjuvant chemotherapy, the material obtained from fine needle aspiration cytology is often the only baseline morphology available for future evaluation. Therefore the assessment of cytological grade in fine needle aspiration cytology samples is useful. In addition, correlating cytological grade with axillary lymph node status is indicative of tumor aggressiveness. This study correlates the cytological grade with histological grade and axillary lymph node status. Methods: Patients with cytological diagnosis of ductal carcinoma who underwent subsequent resection and axillary clearance over a period of five years were included in the study. Fine needle aspiration cytology smears were graded by Robinson’s method and compared with the Modified Bloom Richardson’s histopathological grading and axillary lymph node metastasis.Results: There were a total of 98 cases of invasive ductal carcinoma. Patients’ ages ranged from 28 to 98 years with a mean of 52.17 years. In terms of cytology, there were 22 (22.4%) grade I cases, 61(62.2%) grade II, and 15 (15.3%) grade III. For histopathology, 22 (22.4%) were grade I, 56 (57.1%) were grade II, and 20 (20.4%) were grade III. In 76 (77.5%) cases the cytological grade correlated with histological grade, but did not show any significant positive correlation with axillary lymph node metastasis.Conclusion: Cytological grade can be used as a predictor of histological grade, but may not predict axillary lymph node metastasis in patients with invasive ductal carcinomas.
https://mejc.sums.ac.ir/article_41997_7f0a011d6b1db7135a0849c8405b1781.pdf
2015-04-01
91
96
Gayatri
Ravikumar
gayatri.ravikumar@gmail.com
1
Department of Pathology, St. John’s Medical College, Bangalore, India
LEAD_AUTHOR
Pritilata
Rout
2
Department of Pathology, St. John’s Medical College, Bangalore, India
AUTHOR
ORIGINAL_ARTICLE
A Study on the Efficacy of Spirituality-Based Intervention on Spiritual Well Being of Patients with Leukemia: A Randomized Clinical Trial
Background: Leukemia is the most common malignancy in young adults that has a life-threatening nature which increases the patients' spiritual needs, leading to emergence of spiritual crises. However, evidences indicate that spiritual needs of patients and their spiritual well-being are not emphasized among health care personnel. According to the cultural, religious and social backgrounds as well as contradictory findings in studies, this study intends to determine the effects of a spiritual-based intervention on spiritual well-being of patients with leukemia.Methods: This randomized clinical trial was conducted at Sayyed-Al-Shohada Hospital (Isfahan, Iran) in 2012-2013. We randomly divided 64 adult patients with leukemia into experimental and control groups. In the experimental group, a spiritualbased intervention that included supportive presence and support for religious rituals was implemented for three days. Both groups completed the Palutzian and Ellison Spiritual Well-being Questionnaire before and after the intervention. Data was analyzed using ANCOVA, chi-square, the Mann-Whitney U-test, and paired and independent t-tests in SPSS (Version 18, SPSS Inc., Chicago, IL).Results: There was a significant difference in the scores of the experimental group before and after the intervention (P<0.001). This difference was absent in the control group. According to ANCOVA results, the mean score of spiritual well-being after spiritual-based intervention in the experimental group was more than the mean score of spiritual well-being in the control group. This result was statistically significant (P<0.001, F=63.303)Conclusion: Our spiritual-based intervention promoted the spiritual well-being of patients with leukemia. Therefore, in cases of refractory diseases such as leukemia, nurses should apply a holistic care approach with emphasis on spirituality-based intervention.
https://mejc.sums.ac.ir/article_41999_362d653d734903c1283299ef5e5793b6.pdf
2015-04-01
97
105
Amir
Musarezaie
musarezaie@nm.mui.ac.ir
1
Behavioral Sciences Research Center, Department of Adult Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Mahboube
Ghasemipoor
amir.musarezaie@yahoo.com
2
Department of Adult Health Nursing, Islamic Azad University, Dehaghan Branch, Isfahan, Iran
AUTHOR
Tahere
Momeni-Ghaleghasemi
amir.musarezaie@gmail.com
3
Department of Adult Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Mahnaz
Khodaee
amirrezaie693@yahoo.com
4
Department of Critical Care Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
Fariba
Taleghani
taleghani@nm.mui.ac.ir
5
Nursing and Midwifery Care Research Center, Department of Adult Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
ORIGINAL_ARTICLE
Granulosa Cell Tumor-like Variant of Endometrioid Carcinoma of the Ovary with Osseous Metaplasia: Report of a Rare Case
The sex cord-like variant of endometrioid carcinoma is a rare subtype with a close histological resemblance to the sex cord-stromal tumor of the ovaries, in particular the Sertoli cell tumor. However, very few cases of the granulosa cell tumor-like variant have been reported since it is commonly misdiagnosed as a granulose cell tumor. Immunohistochemistry is useful in the diagnosis of these tumors as they are typically negative for inhibin alpha. We herein describe the histological and immunohistochemical features of a rare case of granulosa cell tumor-like variant of endometrioid carcinoma of the ovary with extensive areas of hyalinization, calcification and osseous metaplasia in a 45-year-old female patient.
https://mejc.sums.ac.ir/article_41990_1cd6815145f6ef08b3caf92061226afc.pdf
2015-04-01
107
110
Kavita
Mardi
kavitamardi@yahoo.co.in
1
Department of Pathology, Indira Gandhi Medical College, Shimla, India
LEAD_AUTHOR
Neelam
Gupta
2
Department of Pathology, Indira Gandhi Medical College, Shimla, India
AUTHOR
Shivani
Sood
shivanisood343@rediff.com
3
Department of Pathology, Indira Gandhi Medical College, Shimla, India
AUTHOR
Manju
Rao
4
Department of Pathology, Indira Gandhi Medical College, Shimla, India
AUTHOR
ORIGINAL_ARTICLE
Humeral Metastasis from Cervical Cancer: A Rare Case Report
Long bone metastasis in cervical cancer is a rare presentation generally seen in the lumbar column or ribs. The reported rates of bone metastases are between 15%-29%. It is associated with poor prognosis. Bone scan and magnetic resonance imaging are useful techniques for diagnosis. In this case report, a 32-year old female with a previous history of cervical carcinoma FIGO stage IIIA presented with severe pain and swelling in her right humerus. X-ray and magnetic resonance imaging findings were non-conclusive and suggestive of a lytic lesion. She was diagnosed with metastatic cervical cancer according to fine needle aspiration cytology. Fine needle aspiration cytology is considered an important means to confirm clinical suspicion of local recurrence or metastasis of a known cancer without subjecting the patient to further surgical intervention. Suspicious bone lesions, especially in the patient with a past history of cancer should be promptly investigated as they can represent evidence of advanced malignant disease, thereby leading to early therapeutic intervention and decreased morbidity in such patients.
https://mejc.sums.ac.ir/article_41993_f6c0ce6c0f033327723a2ee25559483a.pdf
2015-04-01
111
114
Sonia
Chhabra
dr.soniachhabra@gmail.com
1
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
Kanika
Taneja
drkanikataneja09@gmail.com
2
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
LEAD_AUTHOR
Megha
Ralli
drmegharalli@gmail.com
3
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
Sunita
Singh
sunita62@gmail.com
4
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
Aditi
Arora
draditiarora87@gmail.com
5
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
Sohrab
Arora
sohrab.arora@gmail.com
6
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
Pansi
Gupta
pgdoc1703@gmail.com
7
Department of Pathology, Pandit BD Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India
AUTHOR
ORIGINAL_ARTICLE
Primary Ewing’s Sarcoma of the Spine in Pediatric Patients: A Case Series Analysis and Literature Review
Ewing’s sarcoma is a common malignancy of the bone and soft tissues in pediatric patients. It mostly affects the long bones and pelvis, and less commonly the flat bones and vertebrae. Primary Ewing's sarcoma affecting the spine is very rare. The patient has non-specific symptoms for a prolonged period of time before the correct diagnosis is given. Patients can present with acute paraplegia due to spinal cord compression, which needs prompt surgical intervention. Early diagnosis and treatment is important for neurological recovery. The definitive management includes three main modalities: surgery, radiotherapy, and combination chemotherapy. Adequate surgical excision may not be feasible because of anatomical limitations and local control is mainly achieved by radiotherapy. Because of the low incidence of these tumors, a multitude of therapeutic strategies have been employed with varying success. Currently there are no clinical guidelines outlining optimal management. We present a series of six cases of primary Ewing's sarcoma of the spine, analysis of presenting complaints, examination findings, diagnostic investigations, treatment, outcome and review of relevant literature. Five out of the six patients had prolonged musculoskeletal symptoms before they were correctly diagnosed and three presented with acute paraplegia. All have received aggressive multimodality therapy with complete neurological recovery and are surviving.
https://mejc.sums.ac.ir/article_41996_84b47a5b29a4f67bf76b57da6fba1dc9.pdf
2015-04-01
115
120
Manjusha
Nair
drmanjushanair@gmail.com
1
Division of Pediatric Oncology, Regional Cancer Centre, Trivandrum, India
LEAD_AUTHOR
Reghu
Sukumaran Nair
reghuks@gmail.com
2
Division of Pediatric Oncology, Regional Cancer Centre, Trivandrum, India
AUTHOR
Rajeev
Raghavan
rajeev.kath@gmail.com
3
Department of Radiotherapy, Regional Cancer Centre, Trivandrum, India
AUTHOR
Kusumakumary
Parukkutty
renu.sukumaran@gmail.com
4
Division of Pediatric Oncology, Regional Cancer Centre, Trivandrum, India
AUTHOR
Renu
Sukumaran
drkusumamrcc@gmail.com
5
Department of Pathology, Regional Cancer Centre, Trivandrum, India
AUTHOR
ORIGINAL_ARTICLE
Brain Metastasis in a Wilm’s Tumor Patient: A Case Report
The brain is a rare site for metastasis in most extracranial pediatric solid tumors, including Wilm’s tumor. Outcome for these patients are generally dismal. Very few cases have been reported to have good survival even after therapy. This paper reports a case of stage IV Wilm’s tumor with lung metastases in a patient who developed a solitary brain metastasis five months after completion of chemotherapy. She underwent resection of the brain tumor followed by chemotherapy and radiotherapy. The patient was alive at the 20-month follow up after diagnosis of brain metastasis and was considered to have radiologically stable disease.
https://mejc.sums.ac.ir/article_41998_c780b3c6f0285a730ed03dd5523048b2.pdf
2015-04-01
121
124
A H
Shamsiah
dr.okid@yahoo.com
1
Biomedical Imaging Unit, Faculty of Medicine, University Technology Mara, Sungai Buloh, Kuala Lumpur, Selangor, Malaysia
LEAD_AUTHOR
Nur Adura
Yaakup
nur_adura@yahoo.com
2
Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
AUTHOR
ORIGINAL_ARTICLE
A Case of Unilateral Proptosis: What is Your Diagnosis?
https://mejc.sums.ac.ir/article_41989_78dbce46dbc081baeaa21026885b009c.pdf
2015-04-01
125
127
Mahdi
Shahriari
shahryar@sums.ac.ir
1
Amir Oncology Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Fazl
Saleh
salehf@yahoo.com
2
Amir Oncology Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Advanced Cancer Screening Course: An Offer to Improve the Quality of Cancer Education
https://mejc.sums.ac.ir/article_41988_112e5fdc6fccd172fc8b1b130aa79b0e.pdf
2015-04-01
129
130
Shahram
Paydar
paydarsh@gmail.com
1
Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Behnam
Dalfardi
dalfardibeh@gmail.com
2
Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Challenge of Chemotherapy Extravasations
https://mejc.sums.ac.ir/article_41992_eb33dc5a635b70ee4832f3dd526066a0.pdf
2015-04-01
131
132
Mohammad Reza
Bordbar
mbordbar53@gmail.com
1
Hematology-Oncology Division, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Fazl
Saleh
salehf@yahoo.com
2
Hematology-Oncology Division, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Babak
Abdolkarimi
b.abdolkarimi@yahoo.com
3
Hematology-Oncology Division, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Calendar of Events
https://mejc.sums.ac.ir/article_44734_972c30bdfc2ac7277276af7c28f2d749.pdf
2015-04-01
131
131
10.30476/mejc.2019.81480.1015