%0 Journal Article %T Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells %J Middle East Journal of Cancer %I Shiraz University of Medical Sciences %Z 2008-6709 %A Matsuyama, Koki %A Ota, Takeshi %A Baba, Junko %A Miyabayashi, Takao %A Watanabe, Satoshi %A Kagamu, Hiroshi %A Narita, Ichiei %A Nakata, Koh %A Yoshizawa, Hirohisa %D 2011 %\ 01/01/2011 %V 2 %N 1 %P 9-18 %! Eradication of Established Murine Skin Tumors by Cyclic Chemoimmunotherapy with Cyclophosphamide and Effector T Cells %R %X Background: Nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory T cells in the host. However, its efficacy is transient. Here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer.Methods:We examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively transferred effector T cells against 5-day, established MCA205 murine skin sarcomas.Results: Cyclophosphamide administration followed by adoptive immunotherapy augmented the trafficking of effector T cells into established tumors. Further, multiple cyclophosphamide administrations helped effector T cells to persist at the sites. Chemoimmunotherapy achieved complete tumor regression even with the transfer of a limited number of effector T cells (5×106).Conclusion: Cyclic chemoimmunotherapy, which maintains adoptively transferred T cells by impairing regulatory T cells, is a potentially suitable treatment for established tumors. %U https://mejc.sums.ac.ir/article_41889_415d2f51ae81e5540088d9e9f3aa7278.pdf