eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
113
124
42038
Early Breast Cancer Detection in Thermogram Images using Supervised and Unsupervised Algorithms
AmirEhsan Lashkari
lashkari.eng@gmail.com
1
Department of Bio-Medical Engineering, Institute of Electrical Engineering & Information Technology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran
Background: In this paper we compare a highly accurate supervised to an unsupervised technique that uses breast thermal images with the aim of assisting physicians in early detection of breast cancer.Methods: First, we segmented the images and determined the region of interest. Then, 23 features that included statistical, morphological, frequency domain, histogram and gray-level co-occurrence matrix based features were extracted from the segmented right and left breasts. To achieve the best features, feature selection methods such as minimum redundancy and maximum relevance, sequential forward selection, sequential backward selection, sequential floating forward selection, sequential floating backward selection, and genetic algorithm were used. Contrast, energy, Euler number, and kurtosis were marked as effective features.Results: The selected features were evaluated by fuzzy C-means clustering as the unsupervised method and compared with the AdaBoost supervised classifier which has been previously studied. As reported, fuzzy C-means clustering with a mean accuracy of 75% can be suitable for unsupervised techniques.Conclusion: Fuzzy C-means clustering can be a suitable unsupervised technique to determine suspicious areas in thermal images compared to AdaBoost as the supervised technique with a mean accuracy of 88%.
https://mejc.sums.ac.ir/article_42038_f1866ecc8161609de43e26274d554691.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
125
129
42041
Determination of Risk Factors Affecting Survival of Patients with Gastric Adenocarcinoma in Hamadan, Iran
Ghodratollah Roshanaei
gh.roshanaei@umsha.ac.ir
1
Farshad Rostampour
2
Mohammadreza Javadi
3
Sepideh Behnoud
4
Masoud Sabouri Ghannad
sabouri@umsha.ac.ir
5
Modeling of Noncommunicable Diseases Research Center, Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Department of General Surgery, Faculty of Medicine, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran
Department of General Surgery, Faculty of Medicine, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran
Research Center for Molecular Medicine, Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Background: Gastric cancer is the second leading cause of cancer death. The aim of this study was to determine the survival rate affected by risk factors in patients with gastric adenocarcinoma.Methods: We performed this retrospective cohort study on patients diagnosed with gastric adenocarcinoma during 2005-2012 in Hamadan, Iran. All patients with pathological diagnosis enrolled in the study. The effects of patients’ demographical and pathological data were assessed in terms of survival. The univariate and multivariate Weibull models were used to determine the effects of these factors on survival rate. Data was analyzed by SPSS16 and STATA10 software.Results: A total of 112 gastric adenocarcinoma patients were followed. Patients included 74 (66.1%) males. During the follow-up, 102 (91.1) patients died. Patients’ had a mean (SD) survival of 21.9 (1.9) months and a median survival of 15 months. The “one-, three- and five-year survival rates were 62%, 16% and 9% respectively. The results showed that metastasis, chemotherapy, tumor site and grade had statistically significant impacts on patient survival.Conclusion: A potentially important role for tumor grade, tumor site, metastasis, and pathologic stage of disease existed in terms of patient survival after surgery. The current research has indicated that neoadjuvant treatment increased survival in patients with gastric adenocarcinoma. It is expected that the prognostic model based on the mentioned factors may assist individual risk stratification and help in the planning of potential forthcoming studies.
https://mejc.sums.ac.ir/article_42041_1905ac207038afbc8d6ec670b440be18.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
131
136
42044
The Effect of Intensive Intrathecal Chemotherapy on Prognosis of Childhood Lymphoblastic Leukemia with Central Nervous System Involvement: A 20-Year Experience
Mahdi Shahriari
shahryar@sums.ac.ir
1
Department of Pediatrics, Hematology Oncology Branch, Shiraz University of Medical Sciences, Shiraz, Iran
Background: Primary central nervous system involvement and central nervous system relapse are poor prognostic events in acute lymphoblastic leukemia. Due to severe skeletal and endocrine complications of craniospinal radiotherapy, only cranial radiotherapy is advisable. However only 15% of the cases with central nervous system relapse may remain in remission; a second central nervous system or bone marrow relapse is common. Prevention of central nervous system relapse is an extremely important way to decrease both mortality and morbidity in childhood leukemia. Methods: This prospective study was conducted from June 1995 to May 2014. A total of 90 children diagnosed with acute lymphoblastic leukemia enrolled in this study following parental informed consent. There were 30 children with primary central nervous system involvement and 60 that had central nervous system relapse due to acute lymphoblastic leukemia. Patients were randomly divided into two groups: 30 patients in group A (control group) received triple intrathecal injections every 2 months according to high risk acute lymphoblastic leukemia protocols for a total of three years. Group A was divided into the following subgroups: A1 (primary central nervous system involvement; n=15) and A2 (central nervous system relapse; n=15). Group B (case group) comprised 60 patients that received additional triple intrathecal injections during the fourth and fifth years (2 years after discontinuation of maintenance chemotherapy). Group B was subdivided as follows: B1 (primary central nervous system involvement; n=20) and B2 (central nervous system relapse; n=40). For each patient in group A, two age and sex matched patients in group B were enrolled. Patients were followed for 2-15 years. Results: From 15 patients in group A1 (control with primary central nervous system involvement), there were 5 central nervous system relapses, 3 bone marrow relapses, and 2 deaths. Boys had more relapses and deaths than girls (chi square: 15.63; P<0.001). The majority of relapses occurred during the third to fifth years. In group A2 (control group with central nervous system relapse), from 15 patients, there were 7 with second central nervous system relapses, 6 with bone marrow relapses, and 2 deaths. The majority of relapses occurred during the third to fifth years. Boys had more relapses and deaths (P<0.005). From 20 patients in group B1 (cases with primary central nervous system involvement) only 2 boys had central nervous system relapses. There were no bone marrow relapses and no male patients died. No relapse or deaths occurred in female patients (Fisher’s exact test: P<0.001). In group B2 (cases with CNS relapse): 8/40 patients had second central nervous system relapses; 3 had bone marrow relapse; and 2 died (P<0.003). Most relapses occurred during the third to fifth years of maintenance therapy. Overall, boys in groups B1 and B2 had less mortality and morbidity (chi square: 27.6; P<0.001) and better prognosis.Conclusion: Extended intrathecal injections after discontinuation of maintenance chemotherapy is advisable for cases with primary central nervous system involvement and central nervous system relapses. However, we propose that national and international studies with greater number of patients should be conducted.
https://mejc.sums.ac.ir/article_42044_a2f284a19b272e1de8acad4192c1581a.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
137
143
42045
Predictive Factors of Radiation-Induced Lung Toxicity in Lung Cancer Patients: A Retrospective Study
Maher Soliman
maher.soliman@daad-alumni.de
1
Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Background: Radiation-induced lung toxicity is an important dose-limiting toxicity in lung cancer radiotherapy, for which there are no generally accepted predictive factors. This study seeks to identify risk factors associated with the development of severe radiation-induced lung toxicity using clinical and dosimetric parameters.Methods: We reviewed the medical records of 54 patients with histologically proven stage III non-small cell lung cancer treated with three dimensional-conformal radiotherapy at Alexandria Main University Hospital between January 2008 and December 2011. The original treatment plans for those patients were restored and imported to a treatment planning system. Lung dose–volume histograms and various dosimetric parameters were calculated. Univariate and multivariate logistic regression analyses were performed. Results: The following grades of radiation-induced lung toxicity were observed in patients - grade 0: 17 (31.5%), grade 1: 5 (9.3%), grade 2: 13 (24.1%), grade 3: 15 (27.8%), and grade 5: 4 (7.4%). A total of 19 (35.2%) patients developed grade ≥3 and were considered to have an event. Univariate analysis showed that age, presence of chronic obstructive pulmonary disease and location of the primary tumor had significant associations with severe radiation-induced lung toxicity. Other dosimetric variables such as tumor side, histology, forced expiratory volume in 1 s, smoking, and gender showed no significant correlations with severe radiation-induced lung toxicity. Multivariate analysis showed that the presence of chronic obstructive pulmonary disease (P=0.001) and location of the primary tumor (P=0.010) were the only predictive factors for severe radiation-induced lung toxicity.Conclusion: This study demonstrates that patients with chronic obstructive pulmonary disease and lower lung lobe tumors have a high risk of severe radiation- induced lung toxicity when treated with combined chemoradiotherapy. These easily obtained clinical factors should be considered when calculating the risk for radiation- induced lung toxicity.
https://mejc.sums.ac.ir/article_42045_bb2be730d8ba7048e770d28ae8695179.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
145
159
42046
Paget’s Disease of the Female Breast: Clinical Findings and Management in 53 Cases at a Single Institution
Hatem Bouzaiene
hatembouzaiene@yahoo.fr
1
Bassem Mezghani
dr.bassem.mez@gmail.com
2
Maher Slimane
maher_slimane@yahoo.fr
3
Aida Goucha
aida.goucha@yahoo.com
4
Amir Ariane
emir.ariane@gmail.com
5
Lamia Naija
lamia.naija@gmail.com
6
Amor Gamoudi
amor.gamoudi@rns.tn
7
Tarek Dhieb
tarek.bendhieb@rns.tn
8
Khaled Rahal
khaled.benrahal@rns.tn
9
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Pathology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Pathology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Department of Surgical Oncology, Salah Azaïz Institute, Tunis, Tunisia
Background: Mammary Paget’s disease is an uncommon form of primary breast cancer. The aim of this study is to assess our institution’s experience in its management.Methods:We retrospectively reviewed the medical records of 53 female patients with histologically confirmed Paget’s disease, treated at the Salah Azaïz Institute between 2001 and 2010.Results: There were palpable masses in 71.7% of cases, of which 90% revealed invasive carcinoma. Approximately 48% of underlying malignancies were multifocal/multicentric. Overall, invasive carcinoma accounted for 69.8% with a median tumor size of 40 mm, high grade in 62.2%, and negative hormone receptor in 47.6% of cases. There was only one case with direct dermis invasion among those with no underlying invasive carcinoma. After a median follow-up of 45 months, 49% of patients presented with relapse/progression and 47.1% died from their disease. Median overall survival was 67 months, whereas disease-free survival was 65 months. Tumor and node advanced clinical stages correlated with poor survival, as well as the presence of invasive carcinoma with additional negative impacts of large tumor size and lymph node involvement. Tumor stage was the only independent indicator on multivariate analysis. Conclusion: The general trend for decreased incidence of Paget’s disease is noted parallel to earlier breast cancer diagnosis. Paget’s disease is at high risk of multifocal/multicentric underlying tumors. The presence of a palpable mass is almost pathognomonic of invasive neoplasm. The major challenge concerns aggressiveness of surgical procedures with breast and axilla preservation perspectives. Prognosis is mainly determined by that of an eventual underlying breast tumor.
https://mejc.sums.ac.ir/article_42046_b9aad0557e5c1467e17283343254612c.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
161
164
42040
Primary Right Atrial Sarcoma Presenting with Cardiac Tamponade and Massive Pleural Effusion
Seied Hosein Ahmadi
mamohagheghi@gmail.com
1
Shahram Momtahen
shahrammomtahen@yahoo.com
2
Fereshteh Ensani
3
Afsaneh Alikhasi
4
Sanambar Sadighi
5
Farhad Samiee
6
Zahra Sedighi
sedighi_zahra@yahoo.com
7
Mohammad Ali Mohagheghi
hosseinahmaditafti@yahoo.com
8
Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences TUMS, Tehran, I. R. of Iran
Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Sciences TUMS, Tehran, I. R. of Iran
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Department of Radiology, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Department of Hematology Oncology, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Department of Radiotherapy, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Department of Hematology Oncology, Cancer Institute, Imam Khomeini Hospital Center, TUMS, Tehran, I. R. of Iran
Primary cardiac sarcomas are very rare and there is no consensus on management. Clinical presentation is usually late. Despite newer diagnostic technology, prognosis remains dismal. We report a case of right atrial sarcoma in a 28-year-old man who presented with acute cardiac tamponade. Emergency subxiphoid pericardial drainage stabilized the patient's critical condition. The lesion was advanced. Therefore, we only performed a suboptimal surgical resection. Despite planning for radiation, the patient's status deteriorated. Only palliative measures continued during the next four months before his death due to disseminated metastasis and progressive cardiopulmonary failure.
https://mejc.sums.ac.ir/article_42040_dd58d495ff87a4170ba41ebf844332c1.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
165
167
42042
Pancreatic Metastasis from Rectal Gastrointestinal Stromal Tumor: A Case Report
Majid Akrami
akramimd@yahoo.com
1
Saba Ebrahimian
saba_ebr@yahoo.com
2
Sedigheh Tahmasebi
tahmasebikh@gmail.com
3
Abdolrasoul Talei
taleiar@gmail.com
4
Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Gastrointestinal stromal tumors are mesenchymal neoplasms of the gastrointesti- nal tract that originate from all areas of the gastrointestinal tract. Metastases to the liver, peritoneum, bones, lungs and soft tissues have been reported. We present the case of a 47- year-old woman with rectal gastrointestinal stromal tumor that underwent wide local excision. She was treated with imatinib for a few months after surgery. After eight months, she was admitted to the emergency service with complaints of epigastric pain, nausea, vomiting, and anorexia. Imaging studies showed the presence of a pancreatic head tumor and three hepatic masses. The patient underwent exploratory laparatomy. Excisional biopsy of one hepatic mass and core needle biopsy of the pancreatic head mass revealed metastases to the liver and pancreas. During the hospital course the patient's condition deteriorated and she subsequently expired.
https://mejc.sums.ac.ir/article_42042_42aa14fc92d606ff9c98544d2c4fe30b.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
169
172
42043
Mammary Sarcoma - Not Otherwise Specified: A Case Report
Sabah Nemri
dinayef@yahoo.com
1
Nazima Haider
nazima_haider@yahoo.com
2
Sohaila Fatima
sohailafatima@gmail.com
3
Department of Laboratory Medicine, Aseer Central Hospital, Abha, Kingdom of Saudi Arabia
Department of Pathology, King Khalid University, Abha, Kingdom of Saudi Arabia
Department of Pathology, King Khalid University, Abha, Kingdom of Saudi Arabia
Mammary sarcomas are a heterogeneous group of malignant neoplasms that arise from the mammary stroma. Primary sarcomas of the breast are extremely rare and comprise less than 0.1% of all malignant tumors of the breast. We present the case of a 56-year-old female diagnosed as stromal sarcoma, not otherwise specified - a very rare entity.
https://mejc.sums.ac.ir/article_42043_a155baa727bbe3d41c170548119a7858.pdf
eng
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
2008-6687
2016-07-01
7
3
173
173
42039
Calendar of Events
Calendar of Events
https://mejc.sums.ac.ir/article_42039_369e59b3f05e607471f339e1c009edbd.pdf