@article { author = {Elsayed, Walid and Harb, Ola and Obaya, Ahmed and Elsayed, Dalia and Gertallah, Loay and Mawla, Walid and Abd El Fattah, Ahmed}, title = {Expressions of YAP-1, ANXA10, and UNC5D in Tissues of Papillary Thyroid Carcinoma; Prognostic, Pathological, and Clinical Significance}, journal = {Middle East Journal of Cancer}, volume = {14}, number = {1}, pages = {29-40}, year = {2023}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {10.30476/mejc.2022.89869.1551}, abstract = {Background: There is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (PTC) patients. Yes activated protein-1 (YAP-1) has been found to control many targets of Hippo pathway. Annexin family is a huge family playing many roles in cellular processes. Annexin A10 (ANXA10) is a member of annexin family. Uncoordinated-5D (UNC5D), a recently discovered Unc5 family member which is found in normal tissues and downregulated in cancer cell lines and tissues. Aim of the study was to assess the expression of YAP-1, ANXA10, and UNC5D in PTC and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in PTC patients.Method: In the present prospective study, we took samples from 60 patients with PTC and 30 samples from non-neoplastic thyroid tissues for YAP-1, ANXA10, and UNC5D immunohistochemistry. All the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.Results: Upregulation of YAP-1 and ANXA10 in addition to downregulation of UNC5D was found in PTC tissues more than non-neoplastic thyroid tissues. In PTC tissues, there were positive associations between high YAP-1 and ANXA10 expression, low UNC5D expression, tumor size (P = 0.022, 0.011, 0.014), presence of lymph node metastases (P = 0.005, < 0.001, 0.008), and inferior disease-free survival rate (P = 0.003, 0.01, 0.03).Conclusion: Upregulation of YAP-1 and ANXA10 expression and downregulation of UNC5D was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival.}, keywords = {YAP-1 protein,ANXA10,UNC5D,PTC,Immunohistochemistry,Prognosis}, url = {https://mejc.sums.ac.ir/article_48522.html}, eprint = {https://mejc.sums.ac.ir/article_48522_078a3b762f457260ecd86ae43c576777.pdf} }