@article { author = {Kumar, J Sathish and Bhutia, Nim Narboo and Bhutia, Tenzing Jigmee and Malik, Pradip and Singh, Madhumangol and Devi, H Priyoshakhi}, title = {Malignant Tumors of the Larynx: A Clinicopathological Study of 30 Cases}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {71-78}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Background: Cancer of the larynx is a common cancer of the head and neck. This cancer has an established correlation with smoking tobacco and alcohol as causative agents. This study has been conducted in a tertiary hospital in Northeastern India. Minimal data about laryngeal cancer from this area was published in the literature.Methods: This prospective study was conducted for a period of two years and enrolled 30 patients. Patients were diagnosed, staged, and treated for the cancer, then followed for 12 months.Results: This study showed that patients in the sixth decade of life were the most common patients that presented with this cancer. There was a male preponderance. Smoking and alcoholism were the most common associated risk factors. Most patients presented with hoarseness followed by a foreign body sensation in the throat. The majority presented with late stage disease. The most common larynx tumor in this study was glottic carcinoma. All cases were squamous cell carcinoma and most were moderately differentiated. Patients underwent treatment with radiation therapy and chemotherapy.Conclusion: At the one year follow up, 36.67% of patients were found to be in remission. A total of two patients succumbed to this disease.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41991.html}, eprint = {https://mejc.sums.ac.ir/article_41991_ad7ca52d5b788484f1e4c050d441ccf0.pdf} } @article { author = {Faraji-Rad, Mohammad and Khajavi, Mehdi and Arjmand, Mohammad Hassan and Shajari, Esmat and Hamidi Alamdari, Daryoush}, title = {Pro-Oxidant - Antioxidant Balance in Patients with High Grade Glioblastoma Multiform}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {79-83}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {10.30476/MEJC-2015-204}, abstract = {Background: Gliomas are the most common primary brain tumors of the central nervous system. Among a number of different bio-molecular events, molecular connections between oxidative stress pathways and their development is prevalent. Oxidative stress is the consequence of an imbalance between pro-oxidant factors and antioxidant defense. This imbalance may lead to DNA damage and changes in growth and function of cells in the brain. Many evidences show that reactive oxygen species in the mammalian brain are directly responsible for cell and tissue function and dysfunction. A brain tumor is correlated with oxidative stress. In this study, we determine the pro-oxidant – antioxidant balance in patients with grade IV brain tumors (glioblastoma multiforme) by the pro-oxidant – antioxidant assay.Methods: We collected sera from 50 patients with high grade (IV) glioblastoma multiform and 49 healthy subjects. The pro-oxidant - antioxidant assay was measured.Results: There was a significant increase in pro-oxidant - antioxidant values in patients (158.10±85.71 HK unit) compared to the control group (74.54±33.54 HK; P=0.001.Conclusion: The pro-oxidant - antioxidant balance assay can show a high level of pro-oxidants in the sera of patients with glioblastoma which indicates the presence of oxidative stress in this group.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41994.html}, eprint = {https://mejc.sums.ac.ir/article_41994_5d749a12b403a7162bc4f02e0a57e548.pdf} } @article { author = {Sayed, Mona}, title = {Different Fractionation in Whole Brain Irradiation for Multiple Brain Metastases}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {85-90}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Background: This study compared the efficacy of two commonly used fractionation schedules for palliative whole brain irradiation in patients with brain metastases, and assessed the association of the Radiotherapy Therapy Oncology Group (RTOG) Recursive Partitioning Analysis for brain metastases (RPA) to survival with each schedule.Methods: Patients with multiple (more than three) brain metastases were assigned to receive whole brain irradiation in 20 Gy over 5 fractions (group 1) or 30 Gy over 10 fractions (group 2). Primary outcome was response and overall survival in each group. Secondary outcome was the RPA classification relation to overall survival and its possible role in the choice between schedules.Results: There were 54 patients in group 1 and 39 in group 2. There was no significant difference in response (P=0.67) or overall survival between the two groups (P=0.55). However RPA 1 patients had significantly better overall survival than RPA 2 patients in both group 1 (P=0.02) and group 2 (P=0.0014), but no significant difference was found when overall survival of RPA 1 patients of both groups were compared (P=0.47) or that of RPA 2 patients in both groups (P=0.29). Conclusion: The two schedules assessed are comparable in terms of response and overall survival. RPA 1 patients have better overall survival than RPA 2 patients regardless of the fractionation used. A schedule of 20 Gy over 5 fractions should be routinely considered for RPA 2 patients as they are less likely to experience late toxicity. This schedule may be considered for RPA 1 patients, however larger randomized trials are needed to confirm the results and assess differences in neurocognitive function.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41995.html}, eprint = {https://mejc.sums.ac.ir/article_41995_f7dba18ddd80941efc31120359bff587.pdf} } @article { author = {Ravikumar, Gayatri and Rout, Pritilata}, title = {Comparison of Cytological versus Histopathological Grading of Invasive Ductal Carcinoma of the Breast with Correlation of Lymph Node Status}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {91-96}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Background: Invasive ductal carcinoma is one of the most common type of tumors in females, constituting a single large group of breast cancers. There are various prognostic factors, of which tumor grade, size and axillary lymph node metastasis are among the important ones. Fine needle aspiration cytology is a commonly used diagnostic technique in the initial evaluation of breast lumps. In the era of neoadjuvant chemotherapy, the material obtained from fine needle aspiration cytology is often the only baseline morphology available for future evaluation. Therefore the assessment of cytological grade in fine needle aspiration cytology samples is useful. In addition, correlating cytological grade with axillary lymph node status is indicative of tumor aggressiveness. This study correlates the cytological grade with histological grade and axillary lymph node status. Methods: Patients with cytological diagnosis of ductal carcinoma who underwent subsequent resection and axillary clearance over a period of five years were included in the study. Fine needle aspiration cytology smears were graded by Robinson’s method and compared with the Modified Bloom Richardson’s histopathological grading and axillary lymph node metastasis.Results: There were a total of 98 cases of invasive ductal carcinoma. Patients’ ages ranged from 28 to 98 years with a mean of 52.17 years. In terms of cytology, there were 22 (22.4%) grade I cases, 61(62.2%) grade II, and 15 (15.3%) grade III. For histopathology, 22 (22.4%) were grade I, 56 (57.1%) were grade II, and 20 (20.4%) were grade III. In 76 (77.5%) cases the cytological grade correlated with histological grade, but did not show any significant positive correlation with axillary lymph node metastasis.Conclusion: Cytological grade can be used as a predictor of histological grade, but may not predict axillary lymph node metastasis in patients with invasive ductal carcinomas.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41997.html}, eprint = {https://mejc.sums.ac.ir/article_41997_7f0a011d6b1db7135a0849c8405b1781.pdf} } @article { author = {Musarezaie, Amir and Ghasemipoor, Mahboube and Momeni-Ghaleghasemi, Tahere and Khodaee, Mahnaz and Taleghani, Fariba}, title = {A Study on the Efficacy of Spirituality-Based Intervention on Spiritual Well Being of Patients with Leukemia: A Randomized Clinical Trial}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {97-105}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Background: Leukemia is the most common malignancy in young adults that has a life-threatening nature which increases the patients' spiritual needs, leading to emergence of spiritual crises. However, evidences indicate that spiritual needs of patients and their spiritual well-being are not emphasized among health care personnel. According to the cultural, religious and social backgrounds as well as contradictory findings in studies, this study intends to determine the effects of a spiritual-based intervention on spiritual well-being of patients with leukemia.Methods: This randomized clinical trial was conducted at Sayyed-Al-Shohada Hospital (Isfahan, Iran) in 2012-2013. We randomly divided 64 adult patients with leukemia into experimental and control groups. In the experimental group, a spiritualbased intervention that included supportive presence and support for religious rituals was implemented for three days. Both groups completed the Palutzian and Ellison Spiritual Well-being Questionnaire before and after the intervention. Data was analyzed using ANCOVA, chi-square, the Mann-Whitney U-test, and paired and independent t-tests in SPSS (Version 18, SPSS Inc., Chicago, IL).Results: There was a significant difference in the scores of the experimental group before and after the intervention (P<0.001). This difference was absent in the control group. According to ANCOVA results, the mean score of spiritual well-being after spiritual-based intervention in the experimental group was more than the mean score of spiritual well-being in the control group. This result was statistically significant (P<0.001, F=63.303)Conclusion: Our spiritual-based intervention promoted the spiritual well-being of patients with leukemia. Therefore, in cases of refractory diseases such as leukemia, nurses should apply a holistic care approach with emphasis on spirituality-based intervention.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41999.html}, eprint = {https://mejc.sums.ac.ir/article_41999_362d653d734903c1283299ef5e5793b6.pdf} } @article { author = {Mardi, Kavita and Gupta, Neelam and Sood, Shivani and Rao, Manju}, title = {Granulosa Cell Tumor-like Variant of Endometrioid Carcinoma of the Ovary with Osseous Metaplasia: Report of a Rare Case}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {107-110}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {The sex cord-like variant of endometrioid carcinoma is a rare subtype with a close histological resemblance to the sex cord-stromal tumor of the ovaries, in particular the Sertoli cell tumor. However, very few cases of the granulosa cell tumor-like variant have been reported since it is commonly misdiagnosed as a granulose cell tumor. Immunohistochemistry is useful in the diagnosis of these tumors as they are typically negative for inhibin alpha. We herein describe the histological and immunohistochemical features of a rare case of granulosa cell tumor-like variant of endometrioid carcinoma of the ovary with extensive areas of hyalinization, calcification and osseous metaplasia in a 45-year-old female patient.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41990.html}, eprint = {https://mejc.sums.ac.ir/article_41990_1cd6815145f6ef08b3caf92061226afc.pdf} } @article { author = {Chhabra, Sonia and Taneja, Kanika and Ralli, Megha and Singh, Sunita and Arora, Aditi and Arora, Sohrab and Gupta, Pansi}, title = {Humeral Metastasis from Cervical Cancer: A Rare Case Report}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {111-114}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Long bone metastasis in cervical cancer is a rare presentation generally seen in the lumbar column or ribs. The reported rates of bone metastases are between 15%-29%. It is associated with poor prognosis. Bone scan and magnetic resonance imaging are useful techniques for diagnosis. In this case report, a 32-year old female with a previous history of cervical carcinoma FIGO stage IIIA presented with severe pain and swelling in her right humerus. X-ray and magnetic resonance imaging findings were non-conclusive and suggestive of a lytic lesion. She was diagnosed with metastatic cervical cancer according to fine needle aspiration cytology. Fine needle aspiration cytology is considered an important means to confirm clinical suspicion of local recurrence or metastasis of a known cancer without subjecting the patient to further surgical intervention. Suspicious bone lesions, especially in the patient with a past history of cancer should be promptly investigated as they can represent evidence of advanced malignant disease, thereby leading to early therapeutic intervention and decreased morbidity in such patients.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41993.html}, eprint = {https://mejc.sums.ac.ir/article_41993_f6c0ce6c0f033327723a2ee25559483a.pdf} } @article { author = {Nair, Manjusha and Sukumaran Nair, Reghu and Raghavan, Rajeev and Parukkutty, Kusumakumary and Sukumaran, Renu}, title = {Primary Ewing’s Sarcoma of the Spine in Pediatric Patients: A Case Series Analysis and Literature Review}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {115-120}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {Ewing’s sarcoma is a common malignancy of the bone and soft tissues in pediatric patients. It mostly affects the long bones and pelvis, and less commonly the flat bones and vertebrae. Primary Ewing's sarcoma affecting the spine is very rare. The patient has non-specific symptoms for a prolonged period of time before the correct diagnosis is given. Patients can present with acute paraplegia due to spinal cord compression, which needs prompt surgical intervention. Early diagnosis and treatment is important for neurological recovery. The definitive management includes three main modalities: surgery, radiotherapy, and combination chemotherapy. Adequate surgical excision may not be feasible because of anatomical limitations and local control is mainly achieved by radiotherapy. Because of the low incidence of these tumors, a multitude of therapeutic strategies have been employed with varying success. Currently there are no clinical guidelines outlining optimal management. We present a series of six cases of primary Ewing's sarcoma of the spine, analysis of presenting complaints, examination findings, diagnostic investigations, treatment, outcome and review of relevant literature. Five out of the six patients had prolonged musculoskeletal symptoms before they were correctly diagnosed and three presented with acute paraplegia. All have received aggressive multimodality therapy with complete neurological recovery and are surviving.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41996.html}, eprint = {https://mejc.sums.ac.ir/article_41996_84b47a5b29a4f67bf76b57da6fba1dc9.pdf} } @article { author = {Shamsiah, A H and Yaakup, Nur Adura}, title = {Brain Metastasis in a Wilm’s Tumor Patient: A Case Report}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {121-124}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {The brain is a rare site for metastasis in most extracranial pediatric solid tumors, including Wilm’s tumor. Outcome for these patients are generally dismal. Very few cases have been reported to have good survival even after therapy. This paper reports a case of stage IV Wilm’s tumor with lung metastases in a patient who developed a solitary brain metastasis five months after completion of chemotherapy. She underwent resection of the brain tumor followed by chemotherapy and radiotherapy. The patient was alive at the 20-month follow up after diagnosis of brain metastasis and was considered to have radiologically stable disease.}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41998.html}, eprint = {https://mejc.sums.ac.ir/article_41998_c780b3c6f0285a730ed03dd5523048b2.pdf} } @article { author = {Shahriari, Mahdi and Saleh, Fazl}, title = {A Case of Unilateral Proptosis: What is Your Diagnosis?}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {125-127}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41989.html}, eprint = {https://mejc.sums.ac.ir/article_41989_78dbce46dbc081baeaa21026885b009c.pdf} } @article { author = {Paydar, Shahram and Dalfardi, Behnam}, title = {Advanced Cancer Screening Course: An Offer to Improve the Quality of Cancer Education}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {129-130}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41988.html}, eprint = {https://mejc.sums.ac.ir/article_41988_112e5fdc6fccd172fc8b1b130aa79b0e.pdf} } @article { author = {Bordbar, Mohammad Reza and Saleh, Fazl and Abdolkarimi, Babak}, title = {The Challenge of Chemotherapy Extravasations}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {131-132}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {}, abstract = {}, keywords = {}, url = {https://mejc.sums.ac.ir/article_41992.html}, eprint = {https://mejc.sums.ac.ir/article_41992_eb33dc5a635b70ee4832f3dd526066a0.pdf} } @article { author = {}, title = {Calendar of Events}, journal = {Middle East Journal of Cancer}, volume = {6}, number = {2}, pages = {131-131}, year = {2015}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {10.30476/mejc.2019.81480.1015}, abstract = {}, keywords = {}, url = {https://mejc.sums.ac.ir/article_44734.html}, eprint = {https://mejc.sums.ac.ir/article_44734_972c30bdfc2ac7277276af7c28f2d749.pdf} }