@article { author = {Shiri, Zahra and Mansouri, Reza and Haghshenas, Mohammad Reza and Talei, Abdolrasoul and Erfani, Nasrollah}, title = {FOXP3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer}, journal = {Middle East Journal of Cancer}, volume = {10}, number = {4}, pages = {299-304}, year = {2019}, publisher = {Shiraz University of Medical Sciences}, issn = {2008-6709}, eissn = {2008-6687}, doi = {10.30476/mejc.2019.78638.}, abstract = {Background:We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer. Methods: The study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). Polymerase chain reactionrestriction fragment length polymorphism was performed for genotyping. Results: Breast cancer cases had a C allele frequency of 455 (91%) and T allele frequency of 45 (9%). The control group had a C allele frequency of 468 (93.6%) and 32 (6.4%) for the T allele. The CC genotype was present in 206 (82.4%) patients, 43 (17.2%) patients had the CT genotype, and the TT genotype was observed in 1 (0.4%) patient. In the control group, 219 (87.6%) had the CC genotype, whereas 30 (12%) had the CT genotype, and 1 (0.4%) had the TT genotype. Statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (P>0.05). There was no significant association between genotype distribution and patients' clinicopathological factors. Conclusion: Our results do not support an association between the FOXP3 -2383 C/T polymorphism and breast cancer in a population from southern Iran.}, keywords = {Breast cancer,FOXP3 gene,Single Nucleotide Polymorphism,PCR-RFLP}, url = {https://mejc.sums.ac.ir/article_45543.html}, eprint = {https://mejc.sums.ac.ir/article_45543_b052fc37579bded152be65a323991997.pdf} }