Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Chronic Psychosocial Stress in Relation to Cancer
1
8
44680
10.30476/mejc.2019.44680
EN
Liviu
Feller
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences
University, Pretoria, South Africa
0000-0001-8209-153X
Razia Abdool Gafaar
Khammissa
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences
University, Pretoria, South Africa
Raoul
Ballyram
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences
University, Pretoria, South Africa
Rakesh
Chandran
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences
University, Pretoria, South Africa
Johan
Lemmer
Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences
University, Pretoria, South Africa
Journal Article
2018
01
30
Cross-sectional observational studies reveal that cancer is more prevalent in depressed persons. Psychosocial stressors such as depression, anxiety, stressful life events, poverty, and lack of social support may favor carcinogenesis. Cancer acquired under these circumstances has a poor prognosis. Conversely, when cancer has developed in the presence of these factors, effective management or treatment of these psychosocial stressors may bring about increased survival time of the affected persons. The purpose of this narrative literature review is to examine the role that maladaptive stress responses play in cancer initiation and progression. Relevant databases, hand searches and authorative texts were critically analysed and the findings were integrated. Stress is influenced by genetic, environmental, pharmacological, and infectious factors in addition to the chronicity of depression, social isolation, and poor stress-coping capacity. Chronic psychosocial stress-induced maladaptive activation of the neuroendocrine system may dysregulate immunoinflammatory responses, alter oncogene expression, promote tumor-related angiogenesis, and accelerate growth of cancer with stimulation of neuroendocrine activity, which may favor cancer progression. The evidence that associates psychosocial stressors to cancer progression is stronger than the evidence which links the same psychosocial stressors to cancer incidence.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Efficacy and Safety of the Irinotecan, Capecitabine, and Oxaliplatin (IOX) Regimen in Metastatic Gastric Cancer: A Single Arm Phase II Trial
9
16
44691
10.30476/mejc.2019.44691
EN
Saeid
Anvari
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
0000-0002-9402-880X
Kamran
Alimoghaddam
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Amir
Kasaeian
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mohammad
Vaezi
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mohsen
Rajaeinejad
AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA
University of Medical Sciences, Tehran, Iran
Mohammad
Zokaasadi
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
0000-0001-8957-0541
Hosein
Kamranzadeh
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
0000-0002-6227-8994
Ardeshir
Ghavamzadeh
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Journal Article
2017
11
26
Background: Gastric cancer is one of the most common malignancies worldwide with a high case mortality rate. In metastatic gastric cancer, a proper combination of chemotherapy could increase the survival rate. The goal of this study is to evaluate the efficacy and safety of the combination regimen of irinotecan, oxaliplatin, and Xeloda in metastatic gastric cancer.Methods: A total of 45 patients with metastatic gastric cancer and good performance status according to the Eastern Cooperative Oncology Group (score: 0-1) received the irinotecan, oxaliplatin, and Xeloda chemotherapy regimen. Demographic data, responses to treatment, and adverse effects were gathered for all cases. Overall survival and progression-free survival rates for patients were calculated using the Kaplan-Meier estimate. Results: Patients’ mean age was 58.3 ± 11.3 years (range: 24-81). There were 73.4% male patients and 26.6% female patients. Anorexia and weight loss were the most common symptoms. Overall response rate was 50%. The majority of toxicities were anemia, nausea and vomiting (grades 1 and 2), diarrhea (grades 1 and 2), neutropenia, alopecia, and hand and foot syndrome. The one-year progression-free survival rate was 31.5 ± 7.5%, whereas the twoyear progression-free survival rate was zero. The one-year overall survival rate was 34.91 ± 8.5%. Patients had a two-year overall survival rate of 7.7 ± 6.6%. Diffuse type cancer was linked to an inferior outcome.Conclusion: Regardless of our limited number of patients, this combination could be a suitable regimen for metastatic gastric cancer in terms of low toxicity, acceptable response rate, and survival results.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Assessment of Elevated Serum Tumor Markers Carcinoembryonic Antigen (CEA) and Cancer Antigen 15-3 (CA15-3) among Patients with Different Subtypes of Metastatic Breast Cancer
17
22
44681
10.30476/mejc.2019.44681
EN
Ali
Taghizadeh
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
0000-0003-3820-1468
Leila
Pourali
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of
Medical Sciences, Mashhad, Iran
0000-0001-5663-5994
Mona
Joudi
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam
Salehi
Department of Socio-Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Shohreh
Eshghi
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Farnaz
Torabian
Medical Student, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran
Azin
Esmaeelpour
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Journal Article
2018
01
06
Background: Cancer antigen 15-3 and carcinoembryonic antigen are used in clinical and laboratory diagnosis of metastatic breast cancer. Previous studies have noted conflicting results about the association between carcinoembryonic antigen and cancer antigen 15-3 in metastatic breast cancer. The present study examined serum tumor marker levels of carcinoembryonic antigen and cancer antigen 15-3 among patients with different subtypes of metastatic breast cancer.Methods: In this cross-sectional study, we assessed metastatic breast cancer patients diagnosed between 2005 and 2012 who referred to academic Hospitals affiliated with Mashhad University of Medical Sciences. The patients were selected by systematic randomization sampling. Demographic, clinical, pathological, and therapeutic data were collected from patients’ hospital records. Statistical analyses were performed by Statistical Package for the Social Sciences version 16.0 software.Results: A total of 298 eligible patients enrolled in the study. Patients’ median age was 48.39±12.57 years. Elevated serum levels of carcinoembryonic antigen were identified in 65.17% of patients and cancer antigen 15-3 in 57.29% of patients. Based on molecular subtype categorization, 109 (39.5%) patients were human epidermal growth factor receptor 2 negative and 105 (38.0%) patients were in the luminal group. There was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with subtypes of the tumor. The most common sites for metastasis were bones and liver, respectively. However, there was no significant correlation between serum carcinoembryonic antigen and cancer antigen 15-3 with the site of metastasis. There was a significant association between serum carcinoembryonic antigen level and stages IIA and IV.Conclusion: One of the most significant findings of the current study was the increased serum carcinoembryonic antigen and cancer antigen 15-3 levels in most metastatic breast cancer participants. We postulate that regular measurement of serum cancer antigen 15-3 and carcinoembryonic antigen could be useful for earlier detection and prediction of outcomes.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Prognostic Value of KI6 Biomarker to Predict Short Term Prognosis of Low Grade Cervical Intraepithelial Neoplasia in Human Papilloma Virus Negative and Positive Patients
23
29
44682
10.30476/mejc.2019.44682
EN
Leila
Mousavi Seresht
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
0000-0003-3869-4047
Noorieh
Sharifi
Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mona
Najafi
Department of Socio-Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Helena
Azimi
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nooshin
Babapour
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Zohreh
Yousefi
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
0000-0001-6499-6626
Nazanin
Beheshtian
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Yasaman
Nikooiyan
Medical Student, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Journal Article
2018
01
31
Background: Screening of cervical cancer is the most common gynecologic cancer in developing countries. Despite being preventable, but we have still some problems in the screening of this cancer. Recently, many studies have been done on immunohistochemistry to improve screening of cervical intraepithelial neoplasia (CIN) as precancerous lesion. But, majority of the studies are based on cytological samples.The objective of this study was to analyze the correlation KI-67 biomarker and HPV infection in predict short time prognosis in CIN as an alternative or auxiliary method to current screening method in a different geographic population.Methods: This descriptive cohort prospective study included 40 patients with diagnosis of CIN based on cervical punch biopsy samples after colposcopy examination. They were referred to the department of gynecology and oncology of an academic hospital, Mashhad University of 2016 to 2017. All samples were investigated for HR- HPV DNA with Cobas test and immunostaining for KI-67 biomarker. Finally, after one year follow up, prognosis for all patients was evaluated. Data were analyzed by SPSS software program version 23.0 and Mann-Whitney U test and Fisher's exact test. P-value< 0.05 was considered significant.Results: significant difference was found between HR-HPV positive and negative tests in KI-67 expression (P<0.001), but no significant difference was observed in reactivity level (P=0.5), also no significant difference was found in KI-67 expression in metaplastic and non-metaplastic epithelium (P=0.88),.Conclusion: KI-67 biomarker is recommended as complementary screening tests not alternative for differentiating in high risks patients with CIN1. The patients with low KI-67 / HR-HPV positive could be offer for a less aggressive follow-up protocol.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Investigating the Levels of Shed Extracellular Domain of HER2 Protein in the Sera of Bladder Cancer Patients
30
36
44683
10.30476/mejc.2019.44683
EN
Ali
Ariafar
Urology-Oncology Research Cent er, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mehrnoosh
Hasheminejad
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
0000-0002-9479-3165
Shabnam
Abtahi
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
0000-0003-3096-8023
Abbas
Ghaderi
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
0000-0003-0849-3375
Journal Article
2019
01
20
Background: Receptor tyrosine-protein kinase ERBB2, also known as human epidermal growth factor receptor-2 (HER2), is heterogeneously expressed in a variety of human cancers, including bladder cancer. Based on previous studies that show its association with bladder cancer progression, HER2 has been included in novel multiplatform biomarkers for prediction of bladder cancer prognosis. However, the clinical significance of HER2 status remains underinvestigated and poorly linked to the patients’ clinicopathological features. Here, we aim to scrutinize the levels of the extracellular domain of HER2 in the sera of bladder cancer patients and correlate these levels with clinicopathological features of the tumor.Methods: In the present analytical cross-sectional study, we enrolled 60 pathologically confirmed bladder cancer patients along with 20 age-sex matched healthy controls, and compared their serum HER2 levels as measured by enzyme-linked immunosorbent assay.Results:We observed no statistically significant difference when comparing the levels of HER2 in the sera of cases and controls (P>0.05). Interestingly, serum HER2 levels of controls were higher than bladder cancer patients who had lymph node metastasis (P=0.036). Serum levels of HER2 were also higher in controls than bladder cancer patients with perineural invasion (P=0.028). We observed significantly higher HER2 serum levels in transitional cell carcinoma patients in comparison to non-transitional cell carcinoma patients (P=0.016).Conclusion: Our observations are suggestive of the absence of any association between bladder cancer prognostic factors and serum HER2 levels. To draw any definitive conclusion, further studies with larger sample sizes that examine the presence of neutralizing auto-antibodies against serum HER2, immunohistochemistry examination of HER2 in bladder tumor and lymph node samples, and urinary HER2 levels, along with measurement of its serum levels would be helpful.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Role of SIZN1 in Esophageal Squamous Cell Carcinoma
37
42
44684
10.30476/mejc.2019.44684
EN
Mohammad Mahdi
Forghanifard
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
0000-0002-7691-6897
Mohammad Reza
Abbaszadegan
Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Meysam
Moghbeli
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
0000-0001-9680-0309
Journal Article
2018
01
21
Background: Bone morphogenetic proteins are a family of cytokines and growth factors that are involved in tumorigenesis. ZCCHC12 (SIZN1), as a transcriptional coactivator of bone morphogenetic protein signaling, is identified as a positive regulator of central nervous system development during embryogenesis. It positively regulates the CREB and AP1 transcription factors that cooperate with the bone morphogenetic protein signaling pathway. In the present study, SIZN1 mRNA expression was assessed in esophageal squamous cell carcinoma patients.Methods: The levels of SIZN1 mRNA expression in tumor tissues from 50 patients with esophageal squamous cell carcinoma were compared with their corresponding normal margins by using real-time polymerase chain reaction.Results: We observed that 10 out of 50 (20%) cases overexpressed SIZN1, whereas 40 out of 50 (80%) cases showed either normal or under expression of SIZN1. There was a significant correlation between the levels of SIZN1 mRNA expression and tumor depth of invasion (P=0.040). Furthermore, a significant correlation between lymph node metastasis and SIZN1 mRNA expression was observed in esophageal squamous cell carcinoma patients (P=0.036).Conclusion: This study is the first report that has assessed SIZN1 expression in esophageal squamous cell carcinoma patients. SIZN1 can be a potential therapeutic target for primary esophageal squamous cell carcinoma because of its role in the early stages of tumor progression and metastasis.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Process Challenges in Palliative Care for Cancer Patients: A Qualitative Study
43
53
44685
10.30476/mejc.2019.44685
EN
Mojgan
Ansari
Department of Nursing, School of Nursing, Sabzevar University of Medical Sciences, Sabzevar, Iran
0000-0001-9851-2896
Maryam
Rassouli
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
0000-0002-5607-8064
Mohamad Esmaiel
Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
0000-0002-9938-3587
Abbas
Abbaszadeh
Department of Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
0000-0003-0899-0232
Ali
Akbarisari
Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
0000-0001-7755-7665
Shahpar
Haghighat
Breast Cancer Research Center, ACECR, Tehran, Iran
0000-0001-6938-467X
Journal Article
2017
12
28
Background: Quality assessment and service delivery processes for cancer patients are the major components of palliative care. This study intends to explore stakeholder’s perceptions of palliative care process challenges for cancer patients in Iran.Method: In this qualitative study, we conducted 22 semi-structured interviews from February 2016 to August 2017 in hospitals located in Tehran, Iran. Participants were selected through purposive sampling and included cancer patients, their family caregivers, healthcare providers, and policy-makers. The interviews were analyzed by qualitative directed content analysis based on the Donabedian model. In order to assess the accuracy and validity of the study, we used Lincoln and Guba’s four criteria.Results: After analysis of the interviews, we categorized the codes into a main category, “process”, and three identified subcategories – “weakness of stakeholders’ engagement policies”, “standardized care”, and “applying educational and research approaches”.Conclusion: Palliative care in Iran is a recent discipline. The results have shown that the process of providing services requires the attention of the health system to the standard models for providing palliative care services. In addition, it is necessary to train human resources in generalist and specialist palliative care groups, design palliative medicine curricula, inform general public about cancer, and empower patients and caregivers.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Valuable Modern Strategy (ATR-IR) Spectroscopy Technique to Distinguish Between Normal and Lung Cancer Tissue
54
59
44686
10.30476/mejc.2019.44686
EN
Ammar
Alhasan
College of Pharmacy, Al-Muthanna University, Samawah, AL-Muthanna, Iraq
0000-0002-4596-4810
Tammar
Ali
College of Pharmacy, Al-Muthanna University, Samawah, AL-Muthanna, Iraq
0000-0003-1407-4572
Journal Article
2017
10
16
Background: Diagnosis of lung cancer is often delayed because most of the patients are asymptomatic during the primary cancer stages. Infrared spectroscopy is an improved technique compared with the others for identifying abnormal tissue types because of its spatial and spectral capabilities. Therefore, this study is taking an advanced advantage of the physical and optical properties of the attenuated total reflection Fourier-transform infrared system.Methods: The attenuated total reflection Fourier-transform infrared has been applied for cancer detection at infrared wavelengths that range from 4000-400 cm-1. This technique may be a beneficial diagnostic method because it uses the principles of physics, as optics and photonics with a specific wavelength region, which can make an immense difference.Results: The attenuated total reflection Fourier-transform infrared system spectra of normal lung tissue showed main peaks at 3321 and 1637 cm-1, which has been assigned to the OH and C=O function group of amide I and has intensities of approximately 61% (OH) and 76% (C=O). That intensity has been shown to decrease in the cancer tissue. A new peak at 1545 cm-1 appeared in the cancerous tissue, which could be an amide II.Conclusions: The identification of a biochemical component from either normal or cancerous lung tissue would help to evaluate malignant tissue. Thus, the obtained results indicated degradation of the biochemistry component (protein) of the tissue due to carcinogenic disease.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
MRI of Breast Lymphoma: A Report of Two Cases with Emphasis on Diffusion Weighted Imaging and Apparent Diffusion Coefficient Value
60
66
44687
10.30476/mejc.2019.44687
EN
Tanty Ramli Hamid
Marlina
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
Medical Imaging Unit, University of Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia
0000-0002-1355-0621
Syakimah Saidi
Noor Laily
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
Kamila Abu Bakar
Fatimah
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
Radiology Department, Tengku Ampuan Rahimah Hospital, Klang, Selangor, Malaysia
Tan Ling Ling
Sharon
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
Radiology Department, Tengku Ampuan Rahimah Hospital, Klang, Selangor, Malaysia
Abdul Hamid
Shamsiah
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
Medical Imaging Unit, University of Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia
Krishnapillai
Vijayalakshmi
Radiology Department, Tengku Ampuan Rahimah Hospital, Klang, Selangor, Malaysia
Mohd Taib
Nur Aishah
Breast Unit, Department of Surgery, Malaya Medical Centre, Kuala Lumpur, Malaysia
Rahmat
Kartini
Department of Biomedical Imaging, Malaya Research Imaging Centre, Kuala Lumpur, Malaysia
0000-0001-8513-9076
Journal Article
2018
01
26
Breast lymphoma is a rare neoplasm that accounts for approximately 0.04-0.5% of breast malignancies. Most breast lymphomas are B-cell type non-Hodgkin lymphomas. The imaging features of breast lymphoma on mammography and ultrasound are nonspecific. There have been several reports on magnetic resonance imaging characteristics of breast lymphoma but only few have described features on diffusion weighted imaging. Herein, we describe the magnetic resonance imaging findings, with emphasis on diffusion weighted imaging and the apparent diffusion coefficient sequences, of two cases of breast lymphoma and compare them with the magnetic resonance imaging features reported in the literature.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Follicular Dendritic Cell Sarcoma of the Neck Recurring after Trimodality Therapy: A Rare and Aggressive Neoplasm
67
72
44688
10.30476/mejc.2019.44688
EN
Anis
Bandyopadhyay
Department of Radiotherapy, Medical College Kolkata, Kolkata, India
0000-0003-2568-4149
Arvind
Verma
Department of Otorhinolaryngology (ENT), Bankura Sammilani Medical College, Bankura India
Mou
Das
Department of pathology, IPGMER and SSKM Hospital, Kolkata,West Bengal, India
Somrita
Biswas
Department of Radiotherapy, Medical College Kolkata, Kolkata, India
Poulami
Basu
Department of Radiotherapy, Medical College Kolkata, Kolkata, India
Journal Article
2017
11
27
Follicular dendritic cell sarcoma is one of the rare and aggressive neoplasms originating from follicular dendritic cells of lymphoid tissues. It commonly presents as asymptomatic lymphadenopathy, but extranodal involvement such as oral cavity, mediastinum, liver, and spleen are also reported. The disease often has an indolent course. Current knowledge on its pathogenesis is limited and due to its rarity, follicular dendritic cell sarcoma has no definite treatment strategy at present. Here we report a case of a 24-year old male with follicular dendritic cell sarcoma of neck, treated with wide local excision, post operative radiation and chemotherapy, and developing pulmonary metastasis after a disease-free period of 15 months.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Thyroid-like Follicular Carcinoma of the Right Kidney: A Case Report
73
76
44689
10.30476/mejc.2019.44689
EN
Mohammad Hossein
Sanei
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
0000-0002-2886-7365
Behnaz
Sabaghi
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
0000-0002-5244-1321
Roya
Sedighin
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Saeedeh
Alamdari
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Maryam
Katani
Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Journal Article
2018
01
15
Renal cell carcinoma is responsible for approximately 80% of malignant tumors of the kidney. Clear cell, papillary, and chromophobe forms comprise the most frequent histological subtypes of renal cell carcinoma. Thyroid-like follicular renal cell carcinoma is an extremely rare subtype of renal cell carcinoma that resembles thyroid follicular neoplasms. Histologic findings should not be confused with chronic pyelonephritis with thyroidization or renal metastasis of thyroid cell carcinoma. There are few reports of thyroid-like follicular renal cell carcinoma. Here, we report a new case of thyroid -like follicular carcinoma of the kidney diagnosed in a partial nephrectomy specimen in a 62-year-old man.
Shiraz University of Medical Sciences
Middle East Journal of Cancer
2008-6709
10
1
2019
01
01
Calendar of Events
77
44690
10.30476/mejc.2019.44690
EN
Journal Article
2019
01
20