2024-03-28T19:44:49Z
https://mejc.sums.ac.ir/?_action=export&rf=summon&issue=4921
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Breast Cancer: Fear of the Unknown
Ahmad
Mosalaei
N/A
2012
07
01
33
34
https://mejc.sums.ac.ir/article_41859_612770871b5e0369524b751aaabe72ae.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Post-traumatic Growth in Breast Cancer Patients: A Qualitative Phenomenological Study
Rahele
Fallah
Fatemeh
Keshmir
Farah
Lotfi Kashani
Eznollah
Azargashb
Mohammad
Esmaeel Akbari
Background: Studies about cancer-related trauma have shown that psychological reactions to the disease are not exclusively negative but most patients also report positive experiences. These positive perceptions are also called post-traumatic growth and benefit patients psychologically, spiritually, and physically. Therefore, we have conducted a study about how women with breast cancer perceive post- traumatic growth and the recognition of its dimensions in Iran.Methods: This qualitative study was conducted by using Interpretative Phe- nomenological Analysis. A total of 23 women with breast cancer who met the inclusion criteria were selected after which patients completed a researcher-generated open-ended questionnaire. Data were analyzed according to the guidelines for the Interpretative Phenomenological Analysis and Smith method.Results: Participants’ perceptions in this study about post-traumatic growth included three themes: spiritual growth, appreciation of life, and increased personal strengths.Conclusion: Themes found in this study conformed to dimensions according to the Tedeschi and Calhoun theory of post-traumatic growth. However, relations with others were not found in the present study. We propose that interventions should be designed and implemented in order to facilitate and enhance post-traumatic growth.
2012
07
01
35
44
https://mejc.sums.ac.ir/article_41858_81a25e3a60d3af37f0c2d7a8bd94d5c2.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
The Impact of Neo-adjuvant and Adjuvant Chemotherapy in Treatment Outcome of Patients with High Risk Soft Tissue Sarcomas of the Extremities
Rasha
Hamed
Seham
Elkhalk
Sameh
Roshdy
Background: This prospective study assessed the efficacy of neoadjuvant and adjuvant chemotherapy on patients with high risk soft tissue sarcomasof the extremities.Methods: Enrolled patients received the following neoadjuvant chemotherapy: doxorubicin (75 mg/m2) on day1, ifosfamide (2.5 g/m2/d) and mesna (20% of the ifosfamide dose) from days1 to 3, repeated every three weeks for a total of three cycles, followed by surgery and radiotherapy. Patients received an additional three cycles of adjuvant chemotherapy that was the same as the neoadjuvant protocol following completion of radiotherapy.Results: There were 52 patients enrolled in the study, of which 50 were included in data analysis. Neoadjuvant chemotherapy was completed by 90% of enrolled patients and 88% completed all planned chemotherapy. A total of 96% of patients underwent surgery and 92% of these had R0 resections. Postoperative radiotherapy was administered to 96% of patients. The estimated three-year local-regional failure was 10%. Estimated three-year rate for distant disease-free survival was 66% and overall survival was 88%. One patient died with treatment secondary to leukopenic sepsis and respiratory failure. Grades 3-4 toxicities were experienced by 86% of patients of which 84% were grades 3- 4 hematologic toxicities and 38% were grades 3-4 non- hematologic toxicities.Conclusion: The current protocol is feasible and associated with favorable distant disease-free survival, overall survival, and limb preservation. This protocol is tolerable and has a manageable toxicity level.
2012
07
01
45
53
https://mejc.sums.ac.ir/article_41860_9bce25c7d6549630dceeb0d23294f1eb.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Effect of Oral Cryotherapy on Combination Chemotherapy-induced Oral Mucositis: A Randomized Clinical Trial
Abbas
Heydari
Hassan
Sharifi
Roham
Salek
Background: This study assesses the effect of oral cryotherapy on the incidence and severity of chemotherapy-induced oral mucositis in combined chemotherapy regimens.Methods: This was a randomized controlled trial that enrolled 80 cancer patients. We evaluated the primary oral status of all patients prior to chemotherapy. Patients were divided into two groups, experimental and control. The experimental group was given ice to place in their mouths from 5 min before to 5 min after chemotherapy.The control group received no intervention. Both groups were treated with the following chemotherapy regimens: i) 5- fluorouracil + leucovorin; ii) cyclophosphamide + adriamycin + 5-fluorouracil; or iii) cyclophosphamide + methotrexate + fluorouracil. World Health Organization and patient-based oral mucositis scales were used for evaluation.Results: According to the WHO based Oral Mucositis Scale, the incidence of oral mucositis in the intervention group (45%) was significantly lower than the control group (77.5%; P=0.01). The incidence of oral mucositis in the intervention group based on the Patient-Judged Oral Mucositis Scale was lower than the control group. The findings of this study indicated that patients who underwent cryotherapy had less severe oral mucositis based on both WHO (P=0.01) and patient oral mucositis scales (P=0.001).Conclusion: Oral cryotherapy because of its ease of application, tolerability and lack of side effects makes it an important resource for reducing the incidence and severity of oral mucositis. The role of oncology nurses is crucial to the application and success of oral cryotherapy.
2012
07
01
55
64
https://mejc.sums.ac.ir/article_41862_1225daf39656c8bdc4c5eca90894e456.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Concurrent Hypofractionated Three-dimensional Re-irradiation and Temozolomide in Recurrent Malignant Glioma
Doaa Ali
Sharaf Eldeen
Eman Abd
Elkareem Toson
Maiy Abd
Elraheem Alshahat
Ahmed
Taha
Background: This study determines the efficacy and tolerability of hypofraction- ated three-dimensional conformal radiotherapy in conjunction with daily temozolomide in treatment of previously irradiated recurrent malignant glioma.Methods:We enrolled 21 patients diagnosed with recurrent or progressive malignant glioma who previously underwent external beam irradiation. All patients had hypofrac- tionated three-dimensional conformal radiotherapy to a total dose of 30 Gy in six fractions, over a two-week period, concurrent with daily temozolomide (75 mg/m2).Results: At the median follow up of 9.5 months (range: 2.5-42), there were 18 (86%) patients who had died. Median overall survival from the onset of hypofractionated three- dimensional conformal radiotherapy was nine months and median time to progression was five months. There was no detectable severe toxicity. Salvage surgery prior to hypofractionated three-dimensional conformal radiotherapy and planning target volume significantly influenced patient outcome according to multivariate analysis.Conclusion: Hypofractionated conformal re-irradiation concurrent with daily temozolomide is a feasible, well-tolerated treatment for recurrent malignant glioma. Patients with surgical re-resection and smaller planning target volumes have the most favorable outcomes.
2012
07
01
65
73
https://mejc.sums.ac.ir/article_41864_3013aab0afc19a174e237ec10f112bb2.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
A Case of Multiple Myeloma with Lung Involvement
Kaushik
Saha
Niranjan
Sit
Arnab
Maji
Debraj
Jash
Plasmacytoma are extramedullary accumulations of plasma cells. Most extramedullary plasmacytomas are associated with the upper respiratory tract. The lung is rarely involved. We report a rare case of lung plasmacytoma with multiple myeloma. The patient is a 60-year-old male who presented with chest pain and a lung mass visualized on CT scan. A preliminary diagnosis of occult lung cancer with widespread skeletal metastasis was made. The diagnosis of lung plasmacytoma with multiple myeloma was made after extensive investigations.
2012
07
01
75
78
https://mejc.sums.ac.ir/article_41857_09fb407429edd2ca11c5071d2fc2da90.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Long-term Survival of Six Patients with Glioblastoma Multiforme: Case Series and Review of the Literature
Shapour
Omidvari
Hamid
Nasrolahi
Amir Abbas
Kani
Niloofar
Ahmadloo
Ahmad
Mosalaei
Mohammad
Mohammadianpanah
Mansour
Ansari
The median overall survival in glioblastoma multiforme is usually less than one year. Long-term survival is rare and is seen in only 3%-6% of GBM patients. The present study reports the characteristics and treatment outcomes of six cases of glioblastoma multiforme with long-term survival. A literature review is also presented. Between 1990 and 2008, 217 glioblastoma multiforme patients have been treated at our center of which six cases (four males) survived for three years or longer. The mean age of the six cases was 25.7 years. All patients received postoperative radiotherapy with a mean dose of 55 gray and four patients received nitrosourea-based chemotherapy. Patients' mean survival was 5.2 years. The results of this study and review of the literature have indicated that long-term (more than three years) survival is exceptional and mainly observed in younger patients with good performance status and following complete surgical tumor resection.
2012
07
01
79
83
https://mejc.sums.ac.ir/article_41861_cb2d4918908a33c81e9c435a3e4eaab2.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review
Abolfazl
Movafagh
Mehrdad
Hashemi
Mojtaba
Ghadiani
Reza
Mirfakhraei
Hossein
Darvish
Davood
Zare Abdollahi
Hamid
Ghaedi
Shamsi
Safari
Leyla
HaghNejad
Sara
Mosammami
Niloofar
Safavi Naeini
Ramin
Miri
Mostafa
Rezaei Tavirani
Background: According to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. This study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations.Methods:We conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/ chromosomes/Mitelman) databases in addition to other pertinent web references. In addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. Cells were finally treated by the giemsa-trypsin-giemsa banding technique.Results: The result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. We performed karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex karyotype 46,XX,t(9;22;2;5).Conclusion: This study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding these translocations in leukemias.
2012
07
01
85
88
https://mejc.sums.ac.ir/article_41863_a14f5057d18b0fcb6f519a87489fd8c1.pdf
Middle East Journal of Cancer
2008-6709
2008-6709
2012
3
Issue 2-3
Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma
Mehdi
Dehghani
Vahid Mohammad
Karimi
We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to the presence of lambda-type light chains. The patient was treated with desmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.
2012
07
01
89
92
https://mejc.sums.ac.ir/article_41865_f9086255d4a6d0c44c187627faecfa98.pdf