TY - JOUR ID - 44859 TI - Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Shivashankara, Arnadi AU - Tonse, Raees AU - Suresh, Sucharitha AU - George, Thomas AU - Vidyasagar, Mamidipudi Srinivasa AU - Rao, Suresh AU - Baliga,, Manjeshwar Shrinath AD - Departments of Biochemistry Father Muller Medical College, Mangalore, Karnataka, India AD - Radiation Oncology Father Muller Medical College, Mangalore, Karnataka, India AD - Community Medicine, MBBS student, Father Muller Medical College, Mangalore, Karnataka, India AD - Radiation Oncology, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka, India Y1 - 2019 PY - 2019 VL - 10 IS - 2 SP - 103 EP - 110 KW - Head and Neck Cancer KW - Salivary lactate dehydrogenase KW - Mucositis DO - 10.30476/mejc.2019.81573.1027 N2 - Background: In this study, we sought to understand the usefulness of salivary lactatedehydrogenase as a predictive marker for the development of radiation-inducedmucositis.Methods: This was a prospective study with head and neck cancer patients whorequired curative radiotherapy (>60Gy). We collected patients’ saliva before the onsetof radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patientsreceived the stipulated oral and dental care. Data on incidence and severity of mucositiswas collected using a preform sheet and oral mucositis assessment scale published bythe Radiation Therapy Oncology Group throughout the 7-week treatment period.Results: Salivary lactate dehydrogenase increased with exposure to radiation(P<0.0001) and there was an observed association with mucositis severity (P<0.0001;r = 0.515).Conclusion: The present results have established, for the first time, that salivarylactate dehydrogenase could be a useful predictive marker to understand the developmentof radiation-induced mucositis in patients with head and neck cancer. The proximityof the oral cavity for regular observation and saliva collection is an added advantage. UR - https://mejc.sums.ac.ir/article_44859.html L1 - https://mejc.sums.ac.ir/article_44859_25a77eb0a3a8664311a93c181a8dcf2d.pdf ER -