TY - JOUR ID - 42091 TI - Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study JO - Middle East Journal of Cancer JA - MEJC LA - en SN - 2008-6709 AU - Ghanadan, Alireza AU - Ehsani, Amir-Hoshang AU - Farahmand, Ali-Mohammad AU - Mirzaei, Mojtaba AD - Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2017 PY - 2017 VL - 8 IS - 4 SP - 207 EP - 212 KW - Melanoma KW - Tumor infiltrating lymphocytes KW - Tumor stage KW - Immune response KW - Prognostic Factor DO - N2 - Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor cells that have infiltrated tumor nests. In this study, we attempt to evaluate the relationship of tumor infiltrating lymphocytes in malignant melanoma with histopathologic findings, tumor stage, and other prognostic factors. Method: This was a retrospective cross-sectional study. We re-evaluated patients’ specimens and categorized the tumor infiltrating lymphocytes as grades 0, 1, 2, or 3 based on density and distribution of the infiltrating lymphocytes. Results: We enrolled 111 patients with a mean age of 59.33±14.68 years, and a male to female ratio of 1.09. There was no evidence of tumor infiltrating lymphocytes in 17.1% of patients. The melanoma subtypes had the following tumor infiltrating lymphocyte grades: 1 (47.7%), 2 (28.8%), and 3 (6.3%). Cancer stage significantly decreased with increasing grade of tumor infiltrating lymphocyte (P<0.001). Although numerous histopathologic findings had a relationship with tumor infiltrating lymphocytes, only microsatellitosis had a significant relation after adjustments for melanoma stage (P< 0.001). Conclusion: Increased density of tumor infiltrating lymphocytes can show a more effective immune response against melanoma. This response can limit cancer progression and result in tumor diagnosis at lower stages of the disease. UR - https://mejc.sums.ac.ir/article_42091.html L1 - https://mejc.sums.ac.ir/article_42091_2d273a76d6a3c22743b60d93a58b1665.pdf ER -