ORIGINAL_ARTICLE
Evaluation of p53, PTEN and β-catenin Immunoexpressions in Primary Ovarian Epithelial Tumors
Background: Ovarian cancer comprises a heterogeneous group of neoplasms. The prognosis cannot be predicted by histopathologic examination alone. The aim of this study is to evaluate p53, PTEN, and β-catenin expressions in primary ovarian carcinomas in an attempt to find a possible relationship with morphologic parameters and clinical findings.Methods: The study included 100 epithelial ovarian tumors (borderline and carcinomas) from affiliated hospitals of Shiraz university of medical sciences during 2007-2013. Immunohistochemical staining for p53, PTEN, and β-catenin was performed on 65 serous, 18 mucinous, 10 endometrioid, 5 clear cell, and 2 mixed tumors.Results: p53 expression pattern in serous carcinoma significantly differed from endometrioid carcinomas. Strong positivity (2+) in >50% of the tumor cells favored serous carcinoma. PTEN expression significantly differed in mucinous and serous carcinomas as well as in endometrioid carcinoma and borderline endometrioid tumor. There was significantly decreased β-catenin expression in the carcinomas compared with borderline tumors. In all of the different subtypes of ovarian carcinomas, we observed a significant association with decreased β-catenin expression to tumor grade as well as in serous carcinomas with increased nuclear grade, mitosis, and tumor grade. There was no significant relation between expressions of p53, PTEN, and β-catenin in epithelial ovarian tumors to FIGO staging, response to chemotherapy, serum CA- 125 marker, and tumor recurrence.Conclusion: p53 and PTEN are helpful in differentiation of some epithelial ovarian tumor subtypes. In serous carcinomas, diminished expression of β-catenin is associated with higher tumor and nuclear grade. This expression is significantly different in borderline and carcinomas.
https://mejc.sums.ac.ir/article_42000_dfc924413c41db4ac2bb83929e1c2c70.pdf
2015-07-01
135
142
Fatemeh
Sari Aslani
sariasf@sums.ac.ir
1
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Azarmidokht
Momeni
a.momeni2008@gmail.com
2
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mozhdeh
Momtahan
momtahan@sums.ac.ir
3
Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mozhgan
Akbarzadeh Jahromi
akbarzadeh@sums.ac.ir
4
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Amir Reza
Dehghanian
amirreza_d@yahoo.com
5
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Dorna
Motevali
dmotevalli@yahoo.com
6
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
A Survey of the Relationship between Serum Testosterone Level and Expressions of Androgen, Progesterone and Estrogen Receptors and HER2 in Iranian Women with Breast Cancer
Background: Breast cancer is the most common cause of cancer in women. This tumor is hormone dependent tumor and oncologists use estrogen receptor (ER), progesterone receptor (PR) and HER2 for treatment of this malignancy. Androgens like testosterone and their receptors (AR) have a role in the pathophysiology of breast cancer but their clinical values are not clear.Method: AR expression was evaluated in 49 patients with breast cancers using immunohistochemistry. Testosterone was evaluated with ELISA. The relation of clinical characteristics and biomarkers with AR and testosterone were analyzed. According to the percentage of stained cells AR categorized to: AR-absent (0%), AR-poorly (1%-10%), AR-moderately (>10%-50%), and AR-highly (>50%) positive.Results: Among 49 patients with breast cancer, 34% were AR-positive and 44% of ERpositive and 22% of ER negative patients were AR-positive. There was no significant association between mean of testosterone and AR, ER, PR and HER2. AR was positive more frequently but not significantly statistically in older patients and patients less than 45 years of age. Testosterone level was higher in ER positive patients than ER negative and lower in AR positive patients than AR negative patients, but these findings were not statistically significant. ten persent of breast cancers were triple negative and AR was negative in all of them.Conclusion: Androgens and AR have role in pathophysiology of breast cancer and in the future one can use the potency of this pathway for the treatment of breast cancer.
https://mejc.sums.ac.ir/article_42005_272a633088fc9e364f2315b9af57e950.pdf
2015-07-01
143
150
Reza
Vojdani
1
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Bita
Geramizadeh
geramib@gmail.com
2
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Vahid
Mohammadkarimi
vahid.mohammadkarimi@gmail.com
3
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Abdolrasoul
Talei
taleiar@gmail.com
4
Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Alireza
Rezvani
ar.rezvani@hotmail.com
5
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Gita
Dorniani
6
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Akbar
Safaei
safaei32akbar@yahoo.com
7
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Samaneh
Ahsant
8
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Azadeh
Piran
9
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Sedighe
Tahmasebi
10
Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Analysis of Surgically Treated Cutaneous Malignancies in a Tertiary Dermatology Center During a Six-Year Period
Background: Cutaneous malignancies are common in dermatologic practice. Due to their relation to sun exposure the characteristics of these malignancies can differ in various geographic locations. This study intends to determine the characteristics of surgically treated cutaneous malignancies and various surgical modalities that have been applied.Methods: This was a retrospective study of patients with cutaneous malignancies who underwent surgery over a six-year period. Data regarding the general information, type of malignancy, location, surgical margin involvement and specific surgical modalities were recorded and analyzed.Results:A total of 432 patients were included. Basal cell carcinoma was the most common malignancy (82.8%) followed by squamous cell carcinoma (13.4%). Lentigo maligna, keratoacanthoma, basosquamous carcinoma, sebaceous carcinoma and Bowen’s disease accounted for the minority of cases. Patients' mean age was 65.7 years and the most common location was the nose and cheeks. The mean diameter was 2.97 cm. Excision was performed with safe margins. Incomplete excision was seen in 14% of basal cell and 15% of squamous cell carcinoma cases. The most common type of defect closure was a simple closure (43.9%).Conclusion: Basal cell carcinoma is the most common type of cutaneous malignancy. Surgery yields a satisfactory response as treatment for this cutaneous malignancy.
https://mejc.sums.ac.ir/article_42006_d6f3cd1b655839cc0108dc955352b4f6.pdf
2015-07-01
151
156
Farideh
Jowkar
jowkarf@sums.ac.ir
1
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Maryam
Sadati
msadati63@yahoo.com
2
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Fatemeh
Sari Aslani
sariasf@sums.ac.ir
3
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Iman
Ahrari
ahrarii@sums.ac.ir
4
Medical Student, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Feasibility of Breast Conserving Surgery in Stage IIIA Breast Carcinoma Patients in the Absence of Neoadjuvant Therapy
Background: Preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. On the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage IIIA breast cancer without preoperative therapy.Methods: We retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemotherapy and/or endocrinal therapy with whole breast radiation between 2005 and 2012. Of those, 116 patients had stages I and II (group 1) breast cancer, whereas 48 patients had stage IIIA (group 2).Results: After a median follow-up of 40.4 months, 18 (15.5%) patients in group- 1and 8 (16.6%) in group-2 developed ipsilateral breast tumor recurrence (P=0.77). Mean time to tumor recurrence was 19 months in group 1 and 17 months in group 2 (P=0.5). However we found more ipsilateral breast tumor recurrence in hormone negative tumors (P=0.002), high grade tumors (P=0.021), young age (P=0.017) and lymph node positive cases (P=0.011). We observed no significant difference between N1 and N2 lymph node status (P=0.241).Conclusion: Our data suggest that breast-conserving surgery with R0 resection is feasible in stage IIIA cases whenever cosmetic appearance can be maintained as long as surgery will be followed by radiotherapy and chemotherapy. A prospective study with larger numbers is recommended for further evaluation of this issue.
https://mejc.sums.ac.ir/article_42007_e06a6aaa45397a6bd1637ec843246fd6.pdf
2015-07-01
157
164
Abeer
Ibrahim
ab_elsayed2003@yahoo.com
1
Department of Medical Oncology and Hematological Malignancy, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
LEAD_AUTHOR
Anwar
Amin
anwartawfik2010@yahoo.com
2
Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
AUTHOR
Rehab
Hassan
medicine3005@yahoo.com
3
Department of Medical Oncology and Hematological Malignancy, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
AUTHOR
ORIGINAL_ARTICLE
A Comparison of Early Results and Patient Satisfaction Rate between Modified Radical Cystectomy with Mainz II Urinary Diversion and Standard Radical Cystectomy with Continent Ileocecal Urinary Diversion
Background: This study compared the early success, complication and patient satisfaction rates of modified extraperitoneal radical cystectomy (Mainz II urinary diversion) with standard intraperitoneal radical cystectomy (continent ileocecal urinary diversion) in a group of patients with muscle invasive urothelial carcinoma of the urinary bladder.Methods: From September 2009 until November 2013, this randomized study enrolled 60 patients with muscle invasive transitional cell carcinoma of the urinary bladder who underwent radical cystectomy and urinary diversion. The patients were randomly allocated to two groups via block randomization. Group A included 30 patients (28 men and 2 women) who underwent modified small incision extraperitoneal radical cystectomy with a Mainz II urinary diversion. Group B included 30 patients (27 men and 3 women) who had classic intraperitoneal radical cystectomy and ileocecal continent diversion. The data were extracted and analyzed. The patients were followed for one year after surgery.Results: Group A patients had a mean age of 61.47±8.63 years. Group B patients had a mean age of 60.77±6.82 years. There were no statistically significant differences in blood loss, electrolyte and acid-base abnormalities, and early post- operative complication rates between the two groups. However, surgical and hospitalization times were significantly shorter in group A (P<0.001). In addition, patients were mobilized earlier and had shorter nothing by moth time. Patient satisfaction rate was significantly more in group A.Conclusion: Small incision extraperitoneal radical cystectomy and Mainz II urinary diversion is a safe, less complicated, effective and more rapid technique with excellent short term outcome. It seems this technique is a reliable alternative for continent urinary diversion in selected bladder cancer patients, mainly in those with urethral involvement.
https://mejc.sums.ac.ir/article_42008_f476cd4d9f11bbd64fa93be8b191ae0c.pdf
2015-07-01
165
170
Saeed
Shakeri
1
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hossein
Zeighami
2
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
AUTHOR
Mehdi
Salehipour
salehipourmehdi@yahoo.com
3
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hossein
Beik Mohammadloo
4
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Aria
Shakeri
5
University of Toronto, Toronto, Canada
AUTHOR
Arash
Shakeri
6
University of Waterloo, Waterloo, Canada
AUTHOR
Shahryar
Zeighami
zeyghamishahryar@yahoo.com
7
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Hematologic Toxicities in Colorectal Cancer Patients who Received FOLFOX4
Background: Over the past decade, survival from advanced colorectal cancer is increasing. Therefore patients have more exposure to chemotherapy and related toxicities. This study determines how hematologic toxicity patterns affect therapy and care.Methods: From April 2010 to March 2013, we enrolled 127 patients with stages IIb to IV colorectal cancer. Patients underwent complete blood count monitoring prior to and during each cycle of FOLFOX4 chemotherapy. Granulocyte colony stimulating factor was injected if their white blood cells were below 3.5×109/L.Results: The most common hematologic toxicities were grades 1-2 for hemoglobin (76.83%) and leukopenia (26.48%). The least common hematologic toxicity was thrombocytopenia (4.69%) for all grades of platelet toxicity. The median granulocyte colony stimulating factor injection was 3.33 per 12 cycles.Conclusion: Anemia and leukopenia are the most common hematologic abnormalities expected with FOLFOX4 chemotherapy regimens for colorectal cancer. The most important factor for predicting hematologic toxicities in patients who receive chemotherapy for colorectal cancer is the number of chemotherapy cycles.
https://mejc.sums.ac.ir/article_42009_5d2b61dc529e98ac9d239d8dacd7959c.pdf
2015-07-01
171
177
Mehdi
Dehghani
mehdi_dehghani6@yahoo.com
1
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Nematollah
Hafezi
2
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Reza
Vojdani
3
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mani
Ramzi
4
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mojtaba
Karimi
5
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Habib
Nourani
6
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Maryam
Zakerinia
7
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zahra
Bahador
8
Department of Hematology and Oncology, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Color Doppler Ultrasonography in Mapping Oral Squamous Cell Carcinoma
Background: Although Color Doppler Ultrasonography (CDUS) is useful in the diagnosis of various diseases of the head and neck, flow signals in oral malignant masses are less studied; hence the present study assesses the usefulness of Color Doppler Ultrasonography in quantifying oral squamous cell carcinoma (OSCC) vascularization. In addition, we determine the hemodynamic parameters by spectral analysis obtained during a Color Doppler Ultrasonography procedure. We have studied the usefulness of Color Doppler Ultrasonography in mapping oral squamous cell carcinoma of the buccal mucosa, tongue and lip.Methods: This case-control study enrolled 60 subjects aged 20-70 years. Group A constituted 30 cases diagnosed with oral squamous cell carcinoma and Group B constituted 30 healthy controls. Ultrasonographic investigation of each mass was performed. The spectral waveform (time-velocity Doppler spectrum) of the flow signal was analyzed for the pulsatility index, resistive index, peak systolic velocity (m/sec), and end diastolic velocity (m/sec). All patients had real-time, gray-scale sonography and Color Doppler Ultrasonography with spectral wave analysis.Results: The mean value for the resistive index in patients with oral squamous cell carcinoma was 0.40±0.14 whereas for healthy subjects, it was 0.83±0.07. The mean pulsatility index value in malignant patients was 0.86±0.20 while for healthy subjects, it came-out to be 2.61±0.77.Conclusion: These Doppler indices have been shown to be sensitive and specific for the diagnosis of malignant oral tumors. Although Color Doppler Ultrasonography cannot replace histopathological procedures, it plays a definite role as an adjunct to clinical evaluation of oral squamous cell carcinoma patients.
https://mejc.sums.ac.ir/article_42010_ef143fee46652d70e31970eaf6cd7a57.pdf
2015-07-01
179
187
Rahul
Gandhi
1
Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India
AUTHOR
Abhishek
Nayyar
singhabhishek.rims@gmail.com
2
Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India
LEAD_AUTHOR
Rahul
Bhowate
3
Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India
AUTHOR
Sweta
Gandhi
4
Department of Public Health Dentistry, Lata Mangeshkar Dental College and Hospital, Nagpur, Maharashtra, India
AUTHOR
Girish
Dongerwar
5
Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, Maharashtra, India
AUTHOR
ORIGINAL_ARTICLE
Epidemiology of Gastric Cancer in Northwest Iran: 2003-2011
Background: Gastric cancer is the fifth most common cancer in the world and the third leading cause of death from cancer worldwide. This study aims to assess the epidemiology of gastric cancer in Ardabil Province, Iran.Methods: This was a descriptive cross-sectional study performed on 1056 patients with gastric cancer registered in the Ardabil Cancer Registry. Data were collected by a checklist and analyzed by statistical methods in SPSS version 19. Results: Out of 1056 cases, 37% were smokers and 80.9% were illiterate. There were 73.1% male cases. Adenocarcinoma was the most common (89.5%) type of cancer and prevalent in males. The tumors were mostly located in the gastric cardia. Most cases were from rural areas.Conclusion: Results showed that the incidence of gastric cancer in Ardabil Province was higher in males compared to females. Compared to the country standards the incidence of gastric cancer was higher.
https://mejc.sums.ac.ir/article_42004_4f48871b16ae7b1cf56cac392334f158.pdf
2015-07-01
189
193
Firouz
Amani
f.amani@arums.ac.ir
1
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
AUTHOR
Mohammad
Sadrkabir
sadrkabir@gmail.com
2
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
AUTHOR
Saeid
Sadeghieh Ahari
s.sadeghiyeh@arums.ac.ir
3
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
LEAD_AUTHOR
Saeid
Barzghari
s.barzghari@arums.ac.ir
4
Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Abbas
Yazdanbod
a.yazdanbod@arums.ac.ir
5
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
AUTHOR
Ahmad
Sabzevari
ahmadsabzevari@yahoo.com
6
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
AUTHOR
Moghgan
Hadavi
m.ghafarri@arums.ac.ir
7
Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
AUTHOR
ORIGINAL_ARTICLE
Cutaneous Metastasis in a Case of Adenocarcinoma of the Lung: A Cytological Diagnosis
Subcutaneous metastatic nodules are an uncommon first sign of underlying cancer. Cutaneous metastasis occurs in 0.8% to 4% of all cancer patients and less than 5% in those with lung cancer. These metastases are usually single or multiple painless nodules that may be mobile or fixed. Cutaneous metastases from the lung are not very common and indicate a worse prognosis. The limited literature on skin metastases from a primary lung suggests that if other extracutaneous metastases exist, median survival does not exceed three months; however, if the skin is the only site of metastatic disease, survival can reach ten months. Fine needle aspiration cytology is an excellent noninvasive method for early diagnosis of subcutaneous nodules, which in the presence of characteristic cytomorphology obviates the need for more invasive methods and surgery. Once diagnosed, the aim is to start treatment as soon as possible before widespread visceral metastases occur. Although the response to chemotherapy is poor, possibly due to poor blood supply to the skin, monitoring response to chemotherapy is easier when such lesions are present.We hereby describe the case of a 38-year-old male who presented with a mass in the right lung along with a nodule on his scalp. Fine needle aspiration cytology from both sites revealed cytological features of adenocarcinoma.
https://mejc.sums.ac.ir/article_42003_93483e08e2c67cda15417f0463b4c4fb.pdf
2015-07-01
195
198
Gajender
Singh
drgajender@rediffmail.com
1
Department of Pathology, Pt. B D Sharma PGIMS Rohtak, Haryana, India
AUTHOR
Ashima
Batra
drashimabatra@gmail.com
2
Department of Pathology, Pt. B D Sharma PGIMS Rohtak, Haryana, India
LEAD_AUTHOR
Sant Prakash
Kataria
drkatariasp@rediffmail.com
3
Department of Pathology, Pt. B D Sharma PGIMS Rohtak, Haryana, India
AUTHOR
Hemant
Yadav
hemantyadav7022@gmail.com
4
Department of Pathology, Pt. B D Sharma PGIMS Rohtak, Haryana, India
AUTHOR
Rajeev
Sen
drrajeevsen@gmail.com
5
Department of Pathology, Pt. B D Sharma PGIMS Rohtak, Haryana, India
AUTHOR
ORIGINAL_ARTICLE
Advanced Radiation Treatment Planning of Prostate Cancer
https://mejc.sums.ac.ir/article_42002_b3ca29ec4b77157381abdfde657121b6.pdf
2015-07-01
199
200
Katsuya
Narisada
research.research1@yahoo.com
1
Sawami, Tobata-ku, Kitakyushu-shi, Fukuoka, Japan
LEAD_AUTHOR
ORIGINAL_ARTICLE
Calendar of Events
https://mejc.sums.ac.ir/article_42001_52d254246022579a2a0c33d23884d4f6.pdf
2015-07-01
201
201